J Korean Med Sci.  2015 Jul;30(7):988-990. 10.3346/jkms.2015.30.7.988.

Pertussis Prevalence in Korean Adolescents and Adults with Persistent Cough

• Lee SY
• Han SB
• Kang JH
• Kim JS

• KMID: 2164487
• DOI: http://doi.org/10.3346/jkms.2015.30.7.988

Abstract

We investigated the prevalence of pertussis in Korean adolescents and adults with persistent cough. Study population was adolescents (aged 11-20 yr) and adults (> or = 21 yr old) who showed persistent cough of 1-8 weeks' duration. Pertussis was diagnosed by culture, polymerase chain reaction (PCR), and serology. A total of 310 subjects participated in this study, and 76 cases (24.5%) met the criteria for laboratory-confirmed pertussis. The majority of the pertussis cases (66/76) were confirmed by serology, while 3 cases (1.0%) were diagnosed with culture, and 10 cases (3.2%) were detected with PCR. Of the 76 subjects diagnosed with pertussis, 20/86 cases were adolescents and 56/224 cases were adults. Neither adolescents nor adults received adolescent-adult booster against pertussis within the previous 5 yr. Pertussis can be a primary cause of persistent cough in Korean adolescents and adults.

Keyword

Pertussis; Adolescent; Adult; Cough; Korea

MeSH Terms

Adolescent
Adult
Bordetella pertussis/immunology
Child
Cough/*epidemiology
Diphtheria-Tetanus-Pertussis Vaccine/immunology/*therapeutic use
Female
Humans
Immunization, Secondary/*utilization
Male
Republic of Korea/epidemiology
Whooping Cough/*epidemiology/immunology
Young Adult
Diphtheria-Tetanus-Pertussis Vaccine

Reference

1. Lee SY, Kim JS, Ahn JH, Choi JH, Ma SH, Park JS, Kim HM, Kang JH. Immunoassay of diphtheria and tetanus according to ages. Infect Chemother. 2012; 44:62–66.

2. Lee SY, Choi UY, Kim JS, Ahn JH, Choi JH, Ma SH, Park JS, Kim HM, Kang JH. Immunoassay of pertussis according to ages. Korean J Pediatr Infect Dis. 2012; 19:55–60.

3. Korea Centers for Disease Control and Prevention. Communicable diseases surveillance yearbook, 2008. Seoul, Republic of Korea: Korea Centers for Disease Control and Prevention;2009.

4. Korea Centers for Disease Control and Prevention. Infectious diseases surveillance yearbook, 2011. Seoul, Republic of Korea: Korea Centers for Disease Control and Prevention;2012.

5. Wendelboe AM, Van Rie A, Salmaso S, Englund JA. Duration of immunity against pertussis after natural infection or vaccination. Pediatr Infect Dis J. 2005; 24:S58–S61.

6. Plotkin SA. Immunologic correlates of protection induced by vaccination. Pediatr Infect Dis J. 2001; 20:63–75.

7. Choi KM, Kim KH, Kim YJ, Kim JH, Park SE, Lee HJ, Eun BW, Jo DS, Choi EH, Hong YJ. Recommendation for the use of newly introduced Tdap vaccine in Korea. Korean J Pediatr. 2011; 54:141–145.

8. Senzilet LD, Halperin SA, Spika JS, Alagaratnam M, Morris A, Smith B. Sentinel Health Unit Surveillance System Pertussis Working Group. Pertussis is a frequent cause of prolonged cough illness in adults and adolescents. Clin Infect Dis. 2001; 32:1691–1697.

9. Park WB, Park SW, Kim HB, Kim EC, Oh M, Choe KW. Pertussis in adults with persistent cough in South Korea. Eur J Clin Microbiol Infect Dis. 2005; 24:156–158.

10. Kwon HJ, Yum SK, Choi UY, Lee SY, Kim JH, Kang JH. Infant pertussis and household transmission in Korea. J Korean Med Sci. 2012; 27:1547–1551.

11. Reizenstein E, Hallander HO, Blackwelder WC, Kühn I, Ljungman M, Möllby R. Comparison of five calculation modes for antibody ELISA procedures using pertussis serology as a model. J Immunol Methods. 1995; 183:279–290.

12. Greco D, Salmaso S, Mastrantonio P, Giuliano M, Tozzi AE, Anemona A, Ciofi degli Atti ML, Giammanco A, Panei P, Blackwelder WC, et al. A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis. Progetto Pertosse Working Group. N Engl J Med. 1996; 334:341–348.

13. Cherry JD, Grimprel E, Guiso N, Heininger U, Mertsola J. Defining pertussis epidemiology: clinical, microbiologic and serologic perspectives. Pediatr Infect Dis J. 2005; 24:S25–S34.

14. Cornia PB, Hersh AL, Lipsky BA, Newman TB, Gonzales R. Does this coughing adolescent or adult patient have pertussis? JAMA. 2010; 304:890–896.

15. Rendi-Wagner P, Tobias J, Moerman L, Goren S, Bassal R, Green M, Cohen D. The seroepidemiology of Bordetella pertussis in Israel: estimate of incidence of infection. Vaccine. 2010; 28:3285–3290.