Ann Dermatol.  2000 Dec;12(4):259-263. 10.5021/ad.2000.12.4.259.

Expression of Intercellular Adhesion Molecule-l (ICAM-1) in Vascular Endothelium and Keratinocytes of Psoriatic Skin

Abstract

BACKGROUND
The endothelial expresson and upregulation of ICAM-1 and epidermal keratinocyte expression of ICAM-1 are well documented in psoriasis. ICAM-1 mediates the adhesion and trafficking of circulating activated skin-seeking CD45RO+ memory CD4+ T lymphocytes from the vessel into the dermis and epidermis of psoriatic skin by binding to its ligand LFA-1(lymphocyte function-associated antigen-1) expressed on lymphocyte membranes.
OBJECTIVE
The purpose of this study was to investigate the expression of ICAM-1 in vascular endothelium and keratinocyte of psoriatic skin and the difference of ICAM-1 expression between early and fully developed psoriatic lesions.
METHODS
We have studied the expression of ICAM-1 in twelve psoriatic patients who had not been treated for psoriatic lesions for 1 month and three normal human skin samples by immunohistochemical staining using monoclonal antibody against ICAM-1.
RESULTS
Immunohistochemical staining revealed anti-ICAM-1 antibody positively stained only in the subpapillary endothelial cells of normal skin. But in all psoriatic lesions studied, anti- ICAM-1 antibody was stained positively in the endothelium of papillary and subpapillary plexus, and in fully developed psoriatic lesions, anti-ICAM-1 antibody was stained focally in epidermal keratinocytes.
CONCLUSION
The results suggest that ICAM-1 expression on papillary microvessels and keratinocytes may play an important role in the transendothelial and transepidermal migration of lymphocytes from the vessel into the dermis and epidermis of psoriatic skin.

Keyword

Psoriasis; Intercellular adhesion molecule-1 (ICAM-1)

MeSH Terms

Dermis
Endothelial Cells
Endothelium
Endothelium, Vascular*
Epidermis
Humans
Intercellular Adhesion Molecule-1
Keratinocytes*
Lymphocytes
Membranes
Memory
Microvessels
Psoriasis
Skin*
T-Lymphocytes
Up-Regulation
Intercellular Adhesion Molecule-1
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