Pediatr Gastroenterol Hepatol Nutr.  2016 Mar;19(1):44-53. 10.5223/pghn.2016.19.1.44.

Poor Prognostic Factors in Patients with Parenteral Nutrition-Dependent Pediatric Intestinal Failure

Affiliations
  • 1Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea. mjschj@snu.ac.kr
  • 2Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 3Department of Pediatrics, SMG-SNU Boramae Medical Center, Seoul, Korea.

Abstract

PURPOSE
Parenteral nutrition (PN) not only provides nutritional support but also plays a crucial role in the treatment of children with intestinal failure. The aim of this study was to evaluate the clinical significance and clinical outcomes of long-term PN.
METHODS
Retrospective cohort study was conducted using the medical records of patients treated at Seoul National University Children's Hospital. This study included 19 patients who received PN for over six months. Most patients received home PN.
RESULTS
The indications for PN included short bowel syndrome, chronic intestinal pseudo-obstruction, and intractable diarrhea of infancy. The median age of PN initiation was 1.3 years, and the median treatment duration was 2.9 years. Two patients were weaned from PN; 14 continued to receive PN with enteral feedings; and 3 patients died. The overall survival rates at 2 and 5 years were 93.3% and 84.0%, respectively. The incidence of catheter-related bloodstream infections was 2.7/1,000 catheter-days and was associated with younger age at PN initiation and lower initial height Z-score. Six patients developed catheter-related central vein thrombosis, with an incidence of 0.25/1,000 catheter-days. Eleven patients experienced PN-associated liver disease (PNALD), and one patient underwent multi-visceral transplant. The patients with PNALD exhibited lower final heights and body weight Z-scores. All patients experienced micronutrient deficiencies transiently while receiving PN.
CONCLUSION
PN is an important and safe treatment for pediatric intestinal failure. PNALD was linked to final anthropometric poor outcomes. Micronutrient deficiencies were common. Anthropometric measurements and micronutrient levels must be monitored for successful PN completion.

Keyword

Parenteral nutrition; Catheter related infections; Cholestasis; Micronutrients

MeSH Terms

Body Weight
Catheter-Related Infections
Child
Cholestasis
Cohort Studies
Diarrhea
Humans
Incidence
Intestinal Pseudo-Obstruction
Liver Diseases
Medical Records
Micronutrients
Nutritional Support
Parenteral Nutrition
Retrospective Studies
Seoul
Short Bowel Syndrome
Survival Rate
Thrombosis
Veins
Micronutrients

Figure

  • Fig. 1 The lifetime experience of micronutrient deficiencies while receiving parenteral nutrition.

  • Fig. 2 The Kaplan-Meier cumulative survival curve for the patients who received long-term parenteral nutrition treatment. The overall survival rates at 2 and 5 years were 93.3% and 84.0%, respectively. TPN: Total parenteral nutrition.


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