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Relationships of hepatic histopathological findings and bile microbiological aspects with bile duct injury repair surgical outcomes: A historical cohort

Callejas GH, Marques RA, Gestic MA, Utrini MP, Chaim FDM, Chaim EA, Callejas-Neto F, Cazzo E

Backgrounds/Aims: To analyze relationships of hepatic histopathological findings and bile microbiological profiles with perioperative outcomes and risk of late biliary stricture in individuals undergoing surgical bile duct injury (BDI) repair. Methods:...
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Unexplained Marked Elevation of Serum Transaminase Levels in the Third Trime ster of Pregnancy, with Half of the Cases Suspicious of Intrahepatic Cholestasis of Pregnancy

Lim SH, Kim R, Kang HS, Shim SS

Objective: Major causes of markedly elevated serum transaminase levels in the third trimester of pregnancy are severe preeclampsia, HELLP (hemolysis, elevated liver enzymes, and low platelet counts) syndrome, viral hepatitis,...
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Jaundice in Young Children

Choi YH, Lee SB, Cho YJ, Lee SH, Shin SM, Cheon JE

Jaundice in children have various etiologies. Among them, physiological jaundice is a very common disease observed in more than half of full-term neonates. When jaundice persists or develops after 2...
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Peri-Operative Liver Fibrosis and Native Liver Survival in Pediatric Patients with Biliary Atresia: A Systematic Review and Meta-Analysis

Jahangirnia A, Oltean I, Nasr Y, Islam N, Weir A, Nanassy Jd, Nasr A, Demellawy DE

No systematic review to date has examined histopathological parameters in relation to native liver survival in children who undergo the Kasai operation for biliary atresia (BA). A systematic review and meta-analysis...
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Endoscopic ultrasound-guided biliary drainage in malignant distal biliary obstruction

Jang DK

Endoscopic retrograde cholangiopancreatography is the standard therapeutic approach for malignant distal biliary obstruction (MDBO). However, it can be challenging in patients with surgically altered anatomy, pyloric/duodenal obstruction, or failed biliary...
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Primary hepatic sarcoidosis presenting with cholestatic liver disease and mimicking primary biliary cholangitis: a case report

Park YJ, Woo HY, Kim MB, Ahn J, Heo J

Sarcoidosis often involves the liver. However, primary hepatic sarcoidosis confined to the liver without evidence of systemic involvement is rare. We report the case of a 37-year-old man with hepatic...
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Intraductal Radiofrequency Ablation as a Palliative Treatment for Advanced Malignant Hilar Biliary Obstruction

Kang H, Kim EJ, Kim YS

Malignant hilar biliary obstruction (MHBO) frequently accompanies cholestasis and cholangitis, and requires biliary stent placement. To prevent stent occlusion and prolong survival, local ablation therapy can be considered adjunctive...
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Liver Graft Failure after Plastic Stent Removal of an Anastomotic Biliary Stricture

Chun JW, Yi NJ, Kim H, Paik WH

A biliary anastomotic stricture developed 13 months after living donor liver transplantation in a 19-year-old male with congenital hepatic fibrosis. Endoscopic management with balloon dilation followed by the placement of...
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Total Bilirubin Level as a Predictor of Suboptimal Image Quality of the Hepatobiliary Phase of Gadoxetic Acid-Enhanced MRI in Patients with Extrahepatic Bile Duct Cancer

Hwang JA, Min JH, Kim SH, Choi SY, Lee JE, Moon JY

Objective: This study aimed to determine a factor for predicting suboptimal image quality of the hepatobiliary phase (HBP) of gadoxetic acid-enhanced MRI in patients with extrahepatic bile duct (EHD) cancer...
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Liver transplantation in pediatric patients with progressive familial intrahepatic cholestasis: Single center experience of seven cases

Namgoong JM, Hwang S, Kwon H, Ha S, Kim KM, Oh SH, Hong SM

  • KMID: 2526834
  • Ann Hepatobiliary Pancreat Surg.
  • 2022 Feb;26(1):69-75.
  • doi: 0000-0002-9045-2531
Backgrounds/Aims: Progressive familial intrahepatic cholestasis (PFIC) is an autosomal recessive inherited disease requiring liver transplantation (LT). The objective of this study was to investigate the clinicopathological features and posttransplant courses...
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Predictor of Liver Biochemistry Improvement in Patients with Cytomegalovirus Cholestasis after Ganciclovir Treatment

Puspita G, Widowati T, Triono A

Purpose: Cholestasis resulting from cytomegalovirus (CMV)-induced hepatitis manifests in 40% of patients with a CMV infection. Ganciclovir treatment in children with CMV infections has proven to be highly effective. Until...
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The Comparison of Endoscopic Biliary Drainage in Malignant Hilar Obstruction by Cholangiocarcinoma: Bilateral Metal Stents versus Multiple Plastic Stents

Kim JY, Lee Sg, Kang D, Lee DK, Park JK, Lee KT, Lee JK, Lee KH

Background/Aims: For the management of hilar malignant biliary obstruction (HMBO), endoscopic biliary drainage (EBD) is preferred over percutaneous transhepatic biliary drainage (PTBD) because of its convenience. However, there is no...
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Endoscopic Evaluation of Biliary Strictures: Current and Emerging Techniques

Huynh R, Owers C, Pinto C, Nguyen TM, Kwok T

The diagnosis of biliary strictures in clinical practice can be challenging. Discriminating between benign and malignant biliary strictures is important to prevent the morbidity and mortality associated with incorrect diagnoses....
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Niemann-Pick Disease Type C Diagnosed Using Neonatal Cholestasis Gene Panel

Park SW, Park JH, Moon HJ, Shin M, Moon JS, Ko JS

Niemann-Pick disease type C (NPC) is a neurovisceral lysosomal storage disorder caused by mutations in the NPC1 and NPC2 genes. These mutations cause the accumulation of unesterified cholesterol and other...
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Prostate Cancer Presenting with Pruritus and Cholestasis

Kim YH, Park JM, Kang CD, Seo SO, Lee K, Song G

Jaundice is a rare symptom of the paraneoplastic syndrome associated with prostate cancer. We report a case of metastatic prostate cancer that presented as jaundice. There was an absence of...
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Hyperbilirubinemia without biliary obstruction during amoebic liver abscess treated successfully with endoscopic biliary drainage

Jain AK, Jain S, Kaulavkar S, Choudhary A

Amoebic liver abscess with jaundice is not uncommon, but jaundice with intractable pruritus due to it is extremely uncommon. We present a case of amoebic liver abscess who had mild...
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Phenotypic and Molecular Characteristics of Children with Progressive Familial Intrahepatic Cholestasis in South China

Zhang W, Lin R, Lu Z, Sheng H, Xu Y, Li X, Cheng J, Cai Y, Mao X, Liu L

Purpose: Progressive familial intrahepatic cholestasis (PFIC) is a rare genetic autosomal recessive disease caused by mutations in ATP8B1, ABCB11 or ABCB4. Mutational analysis of these genes is a reliable approach...
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Liver Graft Failure and Bile Cast Nephropathy

Mrzljak A, Jurekovic , Novak R, Maksimovic B, Mikulic D, Galesic Ljubanovic D

The consequences of graft failure after liver transplantation (LT) range far beyond the liver. The kidneys are often affected, where persistent and progressive cholestasis can result in acute kidney injury...
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Successful Treatment with Rituximab and Immunoadsorption for an Auto-Antibody Induced Bile Salt Export Pump Deficiency in a Liver Transplanted Patient

Quintero J, Juamperez , Gonzales E, Julio E, Mercadal-Hally M, Collado-Hilly M, Marín-Sánchez A, Charco R

We present an 8 years old girl who was diagnosed at 6 months of age of Progressive Familial Intrahepatic Cholestasis type 2. Although liver transplantation (LT) was classically considered curative...
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A Novel VPS33B Variant Identified by Exome Sequencing in a Patient with Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

Lee MJ, Suh CR, Shin JH, Lee JH, Lee Y, Eun BL, Yoo KH, Shim JO

Arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome is a rare autosomal recessive multisystemic disease that is associated with the liver, kidney, skin, and central nervous and musculoskeletal systems. ARC occurs as a result...
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