J Korean Med Sci.
2013 Jan;28(1):74-79. 10.3346/jkms.2013.28.1.74.
The Indoor Level of House Dust Mite Allergen Is Associated with Severity of Atopic Dermatitis in Children
- Affiliations
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- 1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. kmaped@skku.edu
- 2Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, Korea.
- 3Biostatistics Team, Samsung Biomedical Research Institute, Seoul, Korea.
- 4Department of Pediatrics, Gwangmyeong Sungae Hospital, Gwangmyeong, Korea.
- 5Department of Environmental Medical Biology, Yonsei University College of Medicine, Seoul, Korea.
- 6Department of Pediatrics, Chung-Ang University College of Medicine, Seoul, Korea.
- 7Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
- 8Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, Suwon, Korea.
- KMID: 2158004
- DOI: http://doi.org/10.3346/jkms.2013.28.1.74
Abstract
- We attempted to investigate the correlation between the severity of atopic dermatitis (AD) in children and the indoor level of house dust mite (HDM) allergens. Ninety-five patients (31.1 +/- 19.5 months of age) with AD were enrolled in this study, and serum specific IgE against Dermatophagoides pteronyssinus and D. farinae was measured. The severity of AD was assessed using the visual analogue scale on the same day of house dust collection. Living rooms and mattresses where the child usually slept were vacuumed for 2 minutes and concentrations of Der f 1 were measured by enzyme-linked immunosorbent assay. The skin symptoms were more severe in patients with Der f 1 concentrations in living room > 2 microg/g dust than < or = 2 microg/g dust (P = 0.018). This difference was noted in AD patients without sensitization to HDM (P = 0.004), but not in patients with sensitization. There was no difference in symptom severity according to Der f 1 concentrations in mattresses (P = 0.062). The severity of skin symptoms is associated with indoor concentrations of HDM in children with AD, and it is likely to act as nonspecific irritants as well as allergens in AD skin lesions.
Keyword
MeSH Terms
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Adolescent
Animals
Antigens, Dermatophagoides/*analysis
Beds/parasitology
Child
Child, Preschool
Dermatitis, Atopic/*diagnosis/pathology
Dermatophagoides farinae/immunology
Dermatophagoides pteronyssinus/immunology
*Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin E/blood
Infant
Male
Severity of Illness Index
Antigens, Dermatophagoides
Immunoglobulin E
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