J Korean Med Sci.  2012 Nov;27(11):1433-1435. 10.3346/jkms.2012.27.11.1433.

First Case of Bartonella quintana Endocarditis in Korea

• Lim MH
• Chung DR
• Kim WS
• Park KS
• Ki CS
• Lee NY
• Kim SM

• KMID: 2157959
• DOI: http://doi.org/10.3346/jkms.2012.27.11.1433

Abstract

Since microbial gene sequencing was utilized for etiologic diagnosis of culture-negative endocarditis, cases of Bartonella endocarditis have been reported in various countries. Herein we report the first case of Bartonella quintana endocarditis, which was confirmed for the first time in Korea by 16S rRNA gene sequencing from the excised valve. A 75-yr-old woman was hospitalized due to dyspnea. Echocardiography demonstrated large oscillating vegetation at the aortic valve. Blood culture was negative. She underwent valve replacement and sequencing of the 16S rRNA gene from excised valve identified Bartonella quintana. She was successfully treated with combined use of ceftriaxone and gentamicin.

Keyword

Infective Endocarditis; Bartonella quintana; 16S rRNA; Gene Sequencing

MeSH Terms

Aged, 80 and over
Anti-Bacterial Agents/therapeutic use
Aortic Valve/pathology
Bartonella quintana/genetics/*isolation & purification
Ceftriaxone/therapeutic use
Drug Therapy, Combination
Dyspnea/etiology
Echocardiography
Endocarditis, Bacterial/*diagnosis/drug therapy/microbiology
Female
Gentamicins/therapeutic use
Humans
RNA, Ribosomal, 16S/genetics
Republic of Korea
Sequence Analysis, RNA
Anti-Bacterial Agents
Gentamicins
RNA, Ribosomal, 16S
Ceftriaxone

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