J Korean Med Sci.  2011 Mar;26(3):392-398. 10.3346/jkms.2011.26.3.392.

A Decline in Renal Function is Associated With Loss of Bone Mass in Korean Postmenopausal Women With Mild Renal Dysfunction

• Kim HL
• Park IY
• Choi JM
• Hwang SM
• Kim HS
• Lim JS
• Kim M
• Son MJ

• KMID: 2157877
• DOI: http://doi.org/10.3346/jkms.2011.26.3.392

Abstract

This study was conducted to assess the relationship between estimated glomerular filtration rate (eGFR) and bone mineral density (BMD) in Korean postmenopausal women with mild renal dysfunction. A total of 328 postmenopausal women who underwent BMD measurement during health check-up was investigated. BMD was measured in lumbar spine (L1-L4), femoral neck, total proximal femur and femoral trochanteric areas by dual energy radiography absorptiometry and renal function was estimated by eGFR using Cockcroft-Gault equation. Of the 328 subjects, 317 (96.6%) had an eGFR > or =60 mL/min/1.73 m2. By using simple linear regression analysis, age, height, weight and eGFR were significantly associated with BMD for the 4 aforementioned anatomic sites, while serum levels of creatinine and blood urea nitrogen did not influence BMD. When multiple regression analyses were applied, age and body weight still had significant associations with BMD at 4 different anatomic sites (P < 0.001). A significant association of eGFR with BMD remained in the lumbar spine, femoral neck and proximal total femur (P < 0.05) but not in the trochanteric area (P = 0.300). Our study suggests that a decline of renal function is associated with lower BMD in the lumbar spine, femoral neck and total proximal femur areas in Korean menopausal women with mild renal dysfunction.

Keyword

Association; Bone Density; Koreans; Postmenopause; Renal Insufficiency

MeSH Terms

Absorptiometry, Photon
Aged
Blood Urea Nitrogen
*Bone Density
Creatinine/blood
Female
Femur Neck/physiology
*Glomerular Filtration Rate
Humans
Kidney Diseases/*physiopathology
Kidney Function Tests
Lumbar Vertebrae/physiology
Middle Aged
Osteoporosis, Postmenopausal/*physiopathology
Republic of Korea

Figure

• 

  Fig. 1 Proportion of study participants according to their eGFR values. Participants who had eGFR ≥ 90, 69-89, and 30-59 mL/min/1.73 m2 were 50.9%, 45.7%, and 3.4% of all participants, respectively. eGFR, estimated glomerular filtration rate.

• 

  Fig. 2 Linear associations between eGFR and BMD. Significant positive linear associations between eGFR and BMD are shown in scatterplots. r, Pearson's correlation coefficient. eGFR, estimated glomerular filtration rate; BMD, bone mineral density.

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