J Korean Med Sci.  2005 Dec;20(6):1029-1033. 10.3346/jkms.2005.20.6.1029.

The Prevalence of Metabolic Syndrome in Patients with Gout: A Multicenter Study

• Rho YH
• Choi SJ
• Lee YH
• Ji JD
• Choi KM
• Baik SH
• Chung SH
• Kim CG
• Choe JY
• Lee SW
• Chung WT
• Song GG

• KMID: 2157757
• DOI: http://doi.org/10.3346/jkms.2005.20.6.1029

Abstract

It has been suggested that hyperuricemia and possibly gout are associated with the metabolic syndrome, but there have been no direct studies. This study was undertaken to obtain the prevalence of the metabolic syndrome in patients with gout and to compare it with those from the general population studies. This was a 4-institutional case-historical control study composed of 168 patients with gout. We assessed the prevalence of metabolic syndrome according to the ATP III criteria and compared the prevalence with that of the historical controls. To elucidate the factors in gout that were associated with metabolic syndrome, a multivariate analysis was done. The age-adjusted prevalence of metabolic syndrome in gout patients was 43.6%, which was significantly higher than that of the Korean control population (5.2%) from the previous studies. Patients with gout had more components of metabolic syndrome than did the controls. Body mass index (BMI, OR=1.357 (95%CI 1.111-1.657)) and high density lipoprotein (HDL, OR=0.774 (95%CI 0.705-0.850)) were the variables most significantly associated with the occurrence of metabolic syndrome in gout, but alcohol consumption did not show such associations. Gout is associated with the metabolic syndrome, and furthermore, obesity and dyslipidemia were the factors most associated with the syndrome in these patients.

Keyword

Gout, Metabolic Syndrome X, Hyperuricemia

MeSH Terms

Adult
Aged
Body Mass Index
Case-Control Studies
Gout/*complications
Humans
Korea/epidemiology
Lipoproteins, HDL/blood
Male
Metabolic Syndrome X/*complications/epidemiology/etiology
Middle Aged
Multivariate Analysis
Risk Factors

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