J Korean Neurol Assoc.
2016 Feb;34(1):45-48. 10.17340/jkna.2016.1.8.
Reversible Leukoencephlaopathy Caused by Doxifluridine in a Patient with Gastric Cancer
- Affiliations
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- 1Departments of Neurology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea. jsk120@hanmail.net
- 2Pharmacology and Pharmacogenomics Research Center, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
- KMID: 2153161
- DOI: http://doi.org/10.17340/jkna.2016.1.8
Abstract
- Doxifluridine neurotoxicity is more rare than 5-FU neurotoxicity. We report a case of leukoencephalopathy caused by long-term use of doxifluridine and which was resolved after discontinuation. A 37-year-old woman who had been on doxifluridine for 4 months after gastrectomy presented with dysarthria. Diffusion-weighted MRI imaging revealed multifocal hyperintense lesions in subcortical areas. Her symptoms disappeared after discontinuing doxifluridine, and lesions on follow-up MRI were resolved. These findings suggest that doxifluridine is a plausible cause of reversible leukoencephalopathy.
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