J Korean Soc Radiol.  2016 Feb;74(2):128-131. 10.3348/jksr.2016.74.2.128.

Neurofibroma of the Breast Detected on Positron Emission Tomography-CT in a Patient with Neurofibromatosis Type 1: A Case Report

• Lee H
• Kim HJ
• Yang B
• Lee SM
• Jeong JY

• KMID: 2152605
• DOI: http://doi.org/10.3348/jksr.2016.74.2.128

Abstract

Neurofibromas of the breast are rare. They are commonly found as solitary lesions or parts of neurofibromatosis type 1 and are usually located on the nipple-areolar area. We describe a case of neurofibroma of the breast in the retromammary space, which was detected on positron emission tomography-computed tomography after hysterectomy due to endometrial cancer.

MeSH Terms

Breast*
Electrons*
Endometrial Neoplasms
Female
Humans
Hysterectomy
Mammography
Neurofibroma*
Neurofibromatoses*
Neurofibromatosis 1*
Ultrasonography

Figure

• 

  Fig. 1 Mediolateral-oblique mammography shows a 32 × 19 mm circumscribed mass (arrows) with a partially obscured posterior margin in the posterior right upper breast. Multiple well-circumscribed ovoid lesions in both breasts are surrounded by lucent halos of air, reflecting their superficial location.

• 

  Fig. 2 US (A) and non-enhanced CT scan (B) show a well-circumscribed ovoid mass on the pectoralis major muscle (arrows). PET-CT scan (C) shows mildly increased FDG uptake. The mass (m) abuts the chest wall but is present within the breast. FDG = fluorodeoxyglucose, PET-CT = positron emission tomography-computed tomography, US = ultrasonography

• 

  Fig. 3 Microscopic examination of the specimen. A. A microphotograph of the specimen shows evenly distributed spindle cells with wavy nuclei (hematoxylin-eosin stain, original magnification × 200). B, C. Immunochemical stain for S100 (B) and CD34 (C) show S100 positivity in most, but not all, cells (dark cells) and CD34 positivity in some stromal cells (original magnification × 200).

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