Immune Netw.  2013 Jun;13(3):107-110. 10.4110/in.2013.13.3.107.

Skin Graft-versus-host Disease Following Autologous Stem Cell Transplantation for Multiple Myeloma

Affiliations
  • 1Division of Hematology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea. ckmin@catholic.ac.kr
  • 2Department of Pathology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea.

Abstract

Graft-versus-host disease (GVHD) is a common complication of allogeneic stem cell transplantation (allo-SCT). However, a similar syndrome has been reported in autologous stem cell transplantation (ASCT) as well. The target organs of GVHD in ASCT are the skin, liver and gastrointestinal (GI) tract, which are consistent with those in allo-SCT. Histologic findings from the skin and the mucosa of the GI tract also show similar features. Here we describe a case of autologous GVHD involving the skin of a patient who underwent ASCT for multiple myeloma. In this patient, the response to a total prednisone dose of 0.5 mg/kg/day was unsatisfactory, and the patient required more intensive and prolonged immunosuppressive therapy with slow tapering.

Keyword

Multiple myeloma; Autologous stem cell transplantation; Autologous graft-versus-host disease
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