Immune Netw.  2013 Jun;13(3):107-110. 10.4110/in.2013.13.3.107.

Skin Graft-versus-host Disease Following Autologous Stem Cell Transplantation for Multiple Myeloma

• Lee SE
• Yoon JH
• Shin SH
• Park G
• Min CK

• KMID: 2150774
• DOI: http://doi.org/10.4110/in.2013.13.3.107

Abstract

Graft-versus-host disease (GVHD) is a common complication of allogeneic stem cell transplantation (allo-SCT). However, a similar syndrome has been reported in autologous stem cell transplantation (ASCT) as well. The target organs of GVHD in ASCT are the skin, liver and gastrointestinal (GI) tract, which are consistent with those in allo-SCT. Histologic findings from the skin and the mucosa of the GI tract also show similar features. Here we describe a case of autologous GVHD involving the skin of a patient who underwent ASCT for multiple myeloma. In this patient, the response to a total prednisone dose of 0.5 mg/kg/day was unsatisfactory, and the patient required more intensive and prolonged immunosuppressive therapy with slow tapering.

Keyword

Multiple myeloma; Autologous stem cell transplantation; Autologous graft-versus-host disease

MeSH Terms

Gastrointestinal Tract
Graft vs Host Disease
Humans
Liver
Mucous Membrane
Multiple Myeloma
Prednisone
Skin
Stem Cell Transplantation
Stem Cells
Prednisone

Figure

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  Figure 1 Pathologic findings of skin auto-GVHD.

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  Figure 2 Clinical course of skin auto-GVHD.

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