Korean J Dermatol.  2011 Jan;49(1):45-49.

Cronkhite-Canada Syndrome That Developed in a Patient Taking Levothyroxine Sodium after Total Thyroidectomy

• Baek JH
• Kim TY

Abstract

Cronkhite-Canada Syndrome (CCS) is a rare, non-inherited hamartomatous polyposis syndrome. It is characterized by diffuse gastrointestinal polyposis, diarrhea, weight loss and unique ectodermal manifestations such as alopecia, onychodystrophy and cutaneous hyperpigmentation. The etiology of CCS remains unknown, but an autoimmue contribution to the pathogenesis has been postulated. We report here on a 79-year-old male who has been diagnosed with CCS. He had been taking levothyroxine sodium after total thyroidectomy. To the best of our knowledge, this is the first case report of CCS in association with hypothyroidism and supplementation with levothyroxine sodium in the Korean medical literature.

Keyword

Cronkhite-Canada syndrome; Hypothyroidism; Levothyroxine sodium

MeSH Terms

Aged
Alopecia
Diarrhea
Ectoderm
Humans
Hyperpigmentation
Hypothyroidism
Intestinal Polyposis
Male
Thyroidectomy
Thyroxine
Weight Loss
Thyroxine