Korean Circ J.  2003 Nov;33(11):1028-1035. 10.4070/kcj.2003.33.11.1028.

The Effect of the Probucol-Loaded BiodivYsioTM DD Stent on Inhibition of Neointimal Proliferation in Porcine Coronary Stent Restenosis Model

• Kim W
• Jeong MH
• Cha KS
• Lee SH
• Lim JH
• Kim HG
• Park HW
• Hong YJ
• Park OY
• Kim JH
• Ahn YK
• Park JT
• Kim MH
• Cho JG
• Park JC
• Kang JC

• KMID: 2145613
• DOI: http://doi.org/10.4070/kcj.2003.33.11.1028

Abstract

BACKGROUND AND OBJECTIVES
In a recent multicenter trial probucol was found to reduce stent restenosis by improving the lumen dimension. The probucol was administered for 2 weeks before, and 4 weeks after, stenting. The release of the drug at the site of a vascular injury, via polymer-coated stents, helps achieve an effective local concentration. The feasibility of a probucol stent coating in reducing in-stent restenosis was assessed.
MATERIALS AND METHODS
The probucol loading and in vitro release were assessed using BiodivYsioTM stents, in a 50 mg/mL probucol solution. After being dip-coated with probucol (n=8), or a control (n=8) solution, the stents were implanted in 8 pigs. Angiography and histopathological analyses were performed 28 days later.
RESULTS
The total probucol loading was 52+/-16 microgram/stent, with no release for up to 72 hours after loading. No pig died until sacrifice. On angiography, the reference and minimum lumen diameters showed no significant differences between the two groups, with similar diameters stenosis (8.7+/-3.68 vs. 13.3+/-4.18%, p=0.120). On histomorphometry, the injury scores, vessel, lumen and neointimal areas showed no significant differences between the groups, with similar areas of stenosis (23.1+/-12.39 vs. 25.2+/-8.22%, p=0.671). The degrees of re-endothelialization, inflammation and smooth muscle cell proliferation were not significantly different.
CONCLUSIONS
Probucol can be loaded onto a polymer-coated stent, and does not release from the stent for up to 72 hours after loading. About 52 microgram probucol per stent does not reduce in-stent restenosis in porcine coronary arteries.

Keyword

Probucol; Coronary disease; Restenosis; Stents; Antioxidants

MeSH Terms

Angiography
Antioxidants
Constriction, Pathologic
Coronary Disease
Coronary Vessels
Inflammation
Myocytes, Smooth Muscle
Probucol
Stents*
Swine
Vascular System Injuries
Antioxidants
Probucol