Korean Circ J.  2013 Jul;43(7):443-452. 10.4070/kcj.2013.43.7.443.

The Decline Effect in Cardiovascular Medicine: Is the Effect of Cardiovascular Medicine and Stent on Cardiovascular Events Decline Over the Years?

• Lee MS
• Flammer AJ
• Lerman A

• KMID: 2145499
• DOI: http://doi.org/10.4070/kcj.2013.43.7.443

Abstract

The term decline effect is referred to a diminution of scientifically discovered effects over time. Reasons for the decline effect are multifaceted and include publication bias, selective reporting, outcomes reporting bias, regression to the mean, scientific paradigm shift, overshadowing and habituation, among others. Such effects can be found in cardiovascular medicines through medications (e.g., aspirin, antithrombotics, proton pump inhibitor, beta-blockers, statins, estrogen/progestin, angiotensin converting enzyme inhibitor etc.), as well as with interventional devices (e.g., angioplasty, percutaneous coronary intervention, stents). The scientific community should understand the various dimensions of the decline effects, and effective steps should be undertaken to prevent or recognize such decline effects in cardiovascular medicines.

Keyword

Cardiovascular drug; Stents; Percataneous coronary intervention

MeSH Terms

Angioplasty
Aspirin
Bias (Epidemiology)
Peptidyl-Dipeptidase A
Percutaneous Coronary Intervention
Proton Pumps
Publication Bias
Stents
Aspirin
Peptidyl-Dipeptidase A
Proton Pumps