Nucl Med Mol Imaging.  2007 Aug;41(4):272-279.

The Discriminating Nature of Dopamine Transporter Image in Parkinsonism: The Competency of Dopaminergic Transporter Imaging in Differential Diagnosis of Parkinsonism: 123I-FP-CIT SPECT Study

• Kim BS
• Jang SJ
• Eo JS
• Park EK
• Kim YK
• Kim JM
• Lee WW
• Kim SE

Abstract

PURPOSE: The aim of this study was to evaluate the discriminating nature of 123I-FP-CIT SPECT in patients with parkinsonism.
METHODS
123I-FP-CIT SPECT images acquired from the 18 normal controls; NC (60.4+/-10.0 yr) and 237 patients with parkinsonism (65.9+/-9.2 yr) were analyzed. From spatially normalized images, regional counts of the caudate, putamen, and occipital lobe were obtained using region of interest method. Binding potential (BP) was calculated with the ratio of specific to nonspecific binding activity at equilibrium. Additionally, the BP ratio of putamen to caudate (PCR) and asymmetric index (ASI) were measured.
RESULTS
BPs of NC (3.37+/-0.57, 3.10+/-0.41, 3.23+/-0.48 for caudate, putamen, whole striatum, respectively) had no significant difference with those of essential tremor; ET (3.31+/-0.64, 3.06+/-0.61, 3.14+/-0.63) and Alzheimer's disease; AD (3.33+/-0.60, 3.29+/-0.79, 3.31+/-0.70), but were higher than those of Parkinson's disease; PD (1.92+/-0.74,1.39+/-0.68, 1.64+/-0.68), multiple system atrophy; MSA (2.36+/-1.07, 2.16+/-0.91, 2.26+/-0.96), and dementia with Lewy body; DLB (1.95+/-0.72, 1.64+/-0.65, 1.79+/-0.66)(p<0.005). PD had statistically lower values of PCR and higher values of ASI than those of NC (p<0.005). And PD had significantly lower value of PCR, higher ASI and lower BP in the putamen and whole striatum than MSA (p<0.05).
CONCLUSION
Dopamine transporter image of 123I-FP-CIT SPECT was a good value in differential diagnosis of parkinsonism.

Keyword

dopamine transporter; parkinsonism; 123I-FP-CIT; Parkinson's disease; binding potential

MeSH Terms

Alzheimer Disease
Dementia
Diagnosis, Differential*
Dopamine Plasma Membrane Transport Proteins*
Dopamine*
Essential Tremor
Humans
Lewy Bodies
Multiple System Atrophy
Occipital Lobe
Parkinson Disease
Parkinsonian Disorders*
Polymerase Chain Reaction
Putamen
Tomography, Emission-Computed, Single-Photon*
Dopamine
Dopamine Plasma Membrane Transport Proteins