J Korean Neurol Assoc.
2004 Oct;22(5):524-528.
Serial Follow-up of Neuroimaging Findings in a Progression-free Survival Case with Progressive Multifocal Leukoencephalopathy in Nonimmunocompromised Child
- Affiliations
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- 1Department of Neurology, Yonsei University College of Medicine, Seoul, Korea. scpark@yumc.yonsei.ac.kr
- 2Department of Nuclear Medicine, Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
- 3Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
- 4Department of Neuropathology, Yonsei University College of Medicine, Seoul, Korea.
- 5Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
Abstract
- Progressive multifocal leukoencephalopathy (PML) is a demyelination disease caused by opportunistic infection of the ubiquitous, usually nonpathogenic neurotropic papovavirus (JC virus). The virus infects and destroys myelin-producing oligodendrocytes, thereby causing patchy areas of demyelination in the cerebral white matter. It is exclusively a disease of immunosuppressed individuals. We report a case of an immunocompetent child patient with pathologically-proven PML and with a survival over 3 years after diagnosis. Serial follow up of neuroimaging study including brain MRI, MRS, SPECT and PET was obtained.
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