J Korean Med Assoc.  2007 Feb;50(2):120-126. 10.5124/jkma.2007.50.2.120.

Application of Coronary MDCT Angiography for the Evaluation of Coronary Artery Disease

Affiliations
  • 1Department of Diagnostic Radiology, Seoul National University College of Medicine, Korea. drsic@radiol.snu.ac.kr

Abstract

Despite several limitations, multidetector CT (MDCT) such as 64-slice scanner recently draws attention as the first-line test for the evaluation of chest pain or as a complementary test in patients with equivocal stress test results due to its high negative predictive value and high sensitivity and specificity. In addition, MDCT has the potential as a screening test in asymptomatic patients with a high risk of coronary artery disease. However, the evaluation of in-stent restenosis by MDCT is not infrequently challenging by artifacts caused by metal, especially in smaller stents. In this review, the author will discuss the role of MDCT in patients with suspected coronary artery disease and highlight cardiac MDCT as an emerging diagnostic tool in a routine clinical practice.

Keyword

Coronary artery; Angina; Computed Tomography

MeSH Terms

Angiography*
Artifacts
Chest Pain
Coronary Artery Disease*
Coronary Vessels*
Exercise Test
Humans
Mass Screening
Sensitivity and Specificity
Stents

Figure

  • Figure 1. A 52-year-old man with atypical chest pain, but normal treadmill test. (A) Cardiac MDCT shows tight discrete stenosis (90%) at proximal LAD and os area of 1st diagonal branch (arrow). (B) Conventional coronary angiography reveals tight stenosis at the same area (arrow) and is very well correlated with cardiac MDCT


Reference

References

1. Leschka S, Alkadhi H, Plass A, Desbiolles L, Grunenfelder J, Marincek B, Wildermuth S. Accuracy of MSCT coronary angiography with 64?slice technology: first experience. Eur Heart. 2005; 26:1482–1487.
Article
2. Raff GL, Gallagher MJ, O'Neill WW, Goldstein JA. Diagnostic Accuracy of Noninvasive Coronary Angiography Using 64? Slice Spiral Computed Tomography. J Am Coll Cardiol. 2005; 46:552–557.
3. Mollet NR, Cademartiri F, van Mieghem CA, Runza G, Mc-Fadden EP, Baks T, Serruys PW, Krestin GP, de Feyter PJ. High? resolution spiral computed tomography coronary angiography in patients referred for diagnostic conventional coronary angiography. Circulation. 2005; 112:2318–2323.
4. Herzog C, Britten M, Balzer JO, Mack MG, Zangos S, Ackermann H, Schaechinger V, Schaller S, Flohr T, Vogl TJ. Multi-detector?row cardiac CT: diagnostic value of calcium scoring and CT coronary angiography in patients with symptomatic, but atypical, chest pain. Eur Radiol. 2004; 14:169–177.
Article
5. Schmermund A, Erbel R. Non?invasive computed tomographic coronary angiography: the end of the beginning. Eur Heart J. 2005; 26:145–1453.
6. Garcia MJ. Noninvasive Coronary Angiography: Hype or New Paradigm? JAMA. 2005; 293:2531–2533.
7. Hoffmann U, Moselewski F, Cury RC, Ferencik M, Jang IK, Diaz LJ, Abbara S, Brady TJ, Achenbach S. Predictive value of 16?slice multidetector spiral computed tomography to detect significant obstructive coronary artery disease in patients at high risk for coronary artery disease: patient?versus segment? based analysis. Circulation. 2004; 110:2638–2643.
8. Mollet NR, Cademartiri F, Nieman K, Saia F, Lemos PA, Mc-Fadden EP, Pattynama PM, Serruys PW, Krestin GP, de Feyter PJ. Multislice spiral computed tomography coronary angiography in patients with stable angina pectoris. J Am Coll Cardiol. 2004; 43:2265–2270.
Article
9. Mollet NR, Hoye A, Lemos PA, Cademartiri F, Sianos G, Mc-Fadden EP, Krestin GP, Serruys PW, de Feyter PJ. Value of preprocedure multislice computed tomographic coronary angiography to predict the outcome of percutaneous recanalization of chronic total occlusions. Am J Cardiol. 2005; 95:240–243.
Article
10. White CS, Kuo D, Kelemen M, Jain V, Musk A, Zaidi E, Read K, Sliker C, Prasad R. Chest pain evaluation in the emergency department: can MDCT provide a comprehensive evaluation? Am J Roentgenol. 2005; 185:533–540.
Article
11. Ghersin E, Litmanovich D, Dragu R, Rispler S, Lessick J, Ofer A, Brook OR, Gruberg L, Beyar R, Engel A. 16?MDCT coronary angiography versus invasive coronary angiography in acute chest pain syndrome: a blinded prospective study. Am J Roentgenol. 2006; 186:177–184.
Article
12. Dorgelo J, Willems TP, Geluk CA, Ooijen PM, Zijlstra F, Oudkerk M. Multidetector computed tomography?guided treatment strategy in patients with non?ST elevation acute coronary syndromes: a pilot study. Eur Radiol. 2005; 15:708–713.
Article
13. Hoffman U, Pena AJ, Moselewski F, Ferencik M, Abbara S, Cury RC, Chae CU, Nagurney JT. MDCT in early triage of patients with acute chest pain. Am J Roentgenol. 2006; 187:1240–1247.
14. Herzog C, Dogan S, Diebold T, Khan MF, Ackermann H, Schaller S, Flohr TG, Wimmer?Greinecker G, Moritz A, Vogl TJ. Multi?detector row CT versus coronary angiography: preoperative evaluation before totally endoscopic coronary artery bypass grafting. Radiology. 2003; 229:200–208.
Article
15. Falk V, Mourgues F, Adhami L, Jacobs S, Thiele H, Nitzsche S, Mohr FW, Coste?Maniere E. Cardio navigation: planning, simulation, and augmented reality in robotic assisted endoscopic bypass grafting. Ann Thorac Surg. 2005; 79:2040–2047.
Article
16. Gilard M, Cornily JC, Rioufol G, Finet G, Pennec PY, Man-sourati J, Blanc JJ, Boschat J. Noninvasive assessment of left main coronary stent patency with 16?slice computed tomography. Am J Cardiol. 2005; 95:110–112.
Article
17. Gaspar T, Halon DA, Lewis BS, Adawi S, Schliamser JE, Rubinshtein R, Flugelman MY, Peled N. Diagnosis of coronary in?stent restenosis with multidetector row spiral computed tomography. J Am Coll Cardiol. 2005; 46:1573–1579.
Article
18. Gilard M, Cornily JC, Pennec PY, Le Gal G, Nonent M, Man-sourati J, Blanc JJ, Boschat J. Assessment of coronary artery stents by 16 slice computed tomography. Heart. 2006; 92:58–61.
Article
19. Van Mieghem CA, Cademartiri F, Mollet NR, Malagutti P, Valgimigli M, de Feyter PJ, et al. Multislice spiral computed tomography for the evaluation of stent patency after left main coronary artery stenting: a comparison with conventional coronary angiography and intravascular ultrasound. Circulation. 2006; 114:645–653.
20. Manghat NE, Morgan?Hughes GJ, Marshall AJ, Roobottom CA. Multidetector row computed tomography: imaging congenital coronary artery anomalies in adults. Heart. 2005; 91:1515–1522.
Article
21. Kim SY, Seo JB, Do KH, Heo JN, Lee JS, Song JW, Choe YH, Kim TH, Yong HS, Choi SI, Song KS, Lim TH. Coronary artery anomalies: classification and ECG?gated multi?detector row CT findings with angiographic correlation. Radiographics. 2006; 26:317–333.
Article
22. Schuijf JD, Bax JJ, Jukema JW, Lamb HJ, Vliegen HW, van der Wall EE, de Roos A. Noninvasive evaluation of the coronary arteries with multislice computed tomography in hypertensive patients. Hypertension. 2005; 45:227–232.
Article
23. Schuijf JD, Bax JJ, Jukema JW, Lamb HJ, Vliegen HW, Salm LP, de Roos A, van der Wall EE. Noninvasive angiography and assessment of left ventricular function using multislice computed tomography in patients with type 2 diabetes. Diabetes Care. 2004; 27:2905–2910.
Article
24. Ghostine S, Caussin C, Daoud B, Habis M, Perrier E, Pesenti? Rossi D, Sigal?Cinqualbre A, Angel CY, Lancelin B, Capderou A, Paul JF. Non?invasive detection of coronary artery disease in patients with left bundle branch block using 64?slice computed tomography. J Am Coll Cardiol. 2006; 48:1929–1934.
25. Kondo C, Mori S, Endo M, Kusakabe K, Suzuki N, Hattori A, Kusakabe M. Real?time volumetric imaging of human heart without electrocardiographic gating by 256?detector row computed tomography: initial experience. J Comput Assist Tomogr. 2005; 29:694–698.
26. Budoff MJ, Achenbach S, Blumenthal RS, Carr JJ, Goldin JG, Greenland P, et al. Assessment of CAD by cardiac computed tomography: a scientific statement from the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiology. Circulation. 2006; 114:1761–1791.
27. Hendel RC, Patel MR, Kramer CM, Poon M, Hendel RC, Carr JC, et al. ACCF/ACR/SCCT/SCMR/ASNC/NASCI/SCAI/SIR 2006 Appropriateness Criteria for Cardiac Computed Tomography and Cardiac Magnetic Resonance Imaging: A Report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group, American College of Radiology, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, American Society of Nuclear Cardiology, North American Society for Cardiac Imaging, Society for Cardiovascular Angiography and Interventions, and Society of Interventional Radiology. J Am Coll Cardiol. 2006; 48:1475–1497.
28. Berman DS, Hachamovitch R, Shaw LJ, Friedman JD, Hayes SW, Thomson LE, Fieno DS, Germano G, Slomka P, Wong ND, Kang X, Rozanski A. Roles of nuclear cardiology, cardiac computed tomography, and cardiac magnetic resonance: assessment of patients with suspected coronary artery disease J Nucl Med. 2006; 47:74–82.
29. Berman DS, Hachamovitch R, Shaw LJ, Friedman JD, Hayes SW, Thomson LE, Fieno DS, Germano G, Wong ND, Kang X, Rozanski A. Roles of nuclear cardiology, cardiac computed tomography, and cardiac magnetic resonance: Noninvasive risk stratification and a conceptual framework for the selection of noninvasive imaging tests in patients with known or suspected coronary artery disease. J Nucl Med. 2006; 47:1107–1118.
30. Chang HJ, Choi SI. Era of Multimodality Imaging: Where do we stand? Korean Circulation J. 2006; 36:717–722.
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