J Korean Assoc Oral Maxillofac Surg.  2011 Dec;37(6):470-476. 10.5125/jkaoms.2011.37.6.470.

Retrospective study on the bisphosphonate-related osteonecrosis of jaw

• Han YS
• Lee IW
• Lee H
• Suh JW
• Kim SM
• Myoung H
• Hwang SJ
• Choi JY
• Lee JH
• Choung PH
• Kim MJ
• Seo BM

• KMID: 2136983
• DOI: http://doi.org/10.5125/jkaoms.2011.37.6.470

Abstract

INTRODUCTION
The incidence of bisphosphonate-related osteonecrosis of the jaw (BRONJ) has increased gradually in patients who have undergone surgical treatment for osteomyelitis. In this study, a retrospective analysis of BRONJ patients was carried out using the data of osteomyelitis patients treated surgically.
MATERIALS AND METHODS
Osteomyelitis patients, who underwent curettage, sequestrectomy, saucerization or decortications, and partial mandibulectomy at Seoul National University Dental Hospital from 2004 to 2010 were enrolled in this study. The patients were classified and categorized into two groups based on the surgical records and progress notes. One group comprised of patients with osteomyelitis and osteoporosis, and the other group included patients with osteomyelitis only. The epidemiological data of the BRONJ patients was analyzed to identify any trend in the incidence of BRONJ in osteomyelitis patients.
RESULTS
Among 200 patients who underwent surgical intervention for osteomyelitis, 64 (32.0%) were identified as having osteoporosis as the underlying disease. In these 64 patients, more than 81.3% had been prescribed bisphosphonates. Females were far more affected by BRONJ than males. The incidence of BRONJ also increased with age. The posterior part of the mandible was affected more frequently by BRONJ.
CONCLUSION
Although the availability of potent antibiotics and increased oral hygiene care can reduce the overall incidence of osteomyelitis, BRONJ can increase the total incidence. To prevent BRONJ, it is recommended that an oral examination be performed before prescribing bisphosphonates. Moreover, the patients should be educated about the potential risks of dental procedures that might be causal factors for BRONJ. Furthermore, patient swho take bisphosphonates for the treatment of osteoporosis should undergo periodic follow up oral examinations to prevent BRONJ.

Keyword

Bisphosphonates; Osteonecrosis; Jaw; Osteomyelitis; Osteoporosis

MeSH Terms

Anti-Bacterial Agents
Bisphosphonate-Associated Osteonecrosis of the Jaw
Curettage
Diagnosis, Oral
Diphosphonates
Female
Humans
Incidence
Jaw
Male
Mandible
Oral Hygiene
Osteomyelitis
Osteonecrosis
Osteoporosis
Retrospective Studies
Anti-Bacterial Agents
Diphosphonates

Figure

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  Fig. 1. Types of medications for osteoporosis. Most frequently prescribed drug for osteoporosis is alendronate. Yoon-Sic Han et al: Retrospective study on the bisphosphonate-related osteonecrosis of jaw. J Korean Assoc Oral Maxillofac Surg 2011

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  Fig. 2. Incidence of BRONJ in annual bases. (OM: osteomyelitis, BRONJ: bisphosphonate-related osteonecrosis of jaw) Yoon-Sic Han et al: Retrospective study on the bisphosphonate-related osteonecrosis of jaw. J Korean Assoc Oral Maxillofac Surg 2011

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  Fig. 3. Prevalence of BRONJ in osteomyelitis according to ages. (OM: osteomyelitis, BRONJ: bisphosphonate-related osteonecrosis of jaw) Yoon-Sic Han et al: Retrospective study on the bisphosphonate-related osteonecrosis of jaw. J Korean Assoc Oral Maxillofac Surg 2011

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  Fig. 4. Distribution of osteonecrotic sites of bisphosphonate-related osteonecrosis of jaw. Mandible is more frequent affected area; especially posterior portion of mandible. This diagram showed overlapping incidence of the cases which involved more than one part in the same patient. Yoon-Sic Han et al: Retrospective study on the bisphosphonate-related osteonecrosis of jaw. J Korean Assoc Oral Maxillofac Surg 2011

Reference

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