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Prediction of medication-related osteonecrosis of the jaw (MRONJ) using automated machine learning in patients with osteoporosis associated with dental extraction and implantation: a retrospective study

Kwack DW, Park SM

Objectives: This study aimed to develop and validate machine learning (ML) models using H 2 O-AutoML, an automated ML program, for predicting medication-related osteonecrosis of the jaw (MRONJ) in patients...
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Bone Biopsy Confirmed Imatinib-Induced Bone Marrow Necrosis in Patient with Gastrointestinal Tumor: A Case Report

Kim HJ

Imatinib mesylate is an effective, small-molecule, selective tyrosine kinase inhibitor, which inhibits BCR-ABL in patients with chronic myeloid leukemia, c-kit in patients with gastrointestinal tumor (GIST), and platelet-derived growth factors...
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Texture analysis in cone-beam computed tomographic images of medication-related osteonecrosis of the jaw

Queiroz PM, Fardim KC, Costa ALF, Matheus RA, Lopes SLPC

Purpose: The aim of this study was to evaluate changes in the trabecular bone through texture analysis and compare the texture analysis characteristics of different areas in patients with medication-related...
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Clinical significance of drug cessation on medication-related

Mustakim KR, Eo MY, Lee JY, Seo MH, Kim SM

Objectives: Suspending bisphosphonates (BPs) to reduce the risk and severity of medication-related osteonecrosis of the jaw (MRONJ) remains controversial. In this study, we quantitatively evaluated the clinical significance of BP...
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The effect of drug holiday before tooth extraction on the development of medication-related osteonecrosis of the jaw in cancer patients receiving intravenous bisphosphonates

Karaca , Topaloğlu-Yasan G, Adiloğlu S, Usman E

Objectives: Drug holidays are suggested to reduce the formation of osteonecrosis in patients under intravenous (IV) bisphosphonates (BPs) therapy. The objectives of this study are to evaluate the incidence of medication-related...
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A Case of Inferior Turbinate Osteonecrosis Due to Denosumab

Cho Y, Kim D, Shin JM, Park IH

In rare cases, antiresoprtive medications for osteoporosis cause osteonecrosis. Necrotic bone lesions localized at the jaw after the use of antiresorptive medications is named medicationrelated osteonecrosis of the jaw (MRONJ)....
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Prosthetic Treatment of Implant-supported Double-crown Retained Removable Denture in a Failure Case of Implant-supported Fixed Dental Prosthesis

Park M, Lee DH

A 78-year-old female patient presented with implant failure in the maxillary and mandibular anterior areas due to medication-related osteonecrosis of the jaw. Implant-supported fixed dental prosthesis (FDP) in the maxilla...
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Avascular Necrosis of the Capitate: MRI and Surgical Decision-Making of Two Case Reports

Yoo H, Ahn KS, Lee HG, Kang CH

Avascular necrosis (AVN) is a rare disease occurring in the capitate of the wrist which is the third most common site of AVN among carpal bones. There are few reports...
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Hip Resurfacing Arthroplasty after Failure of Tantalum Rod Insertion in Patients with Osteonecrosis of the Femoral Head

Cho YJ, Rhyu KH, Chun YS, Gwak HG

Purpose: The purpose of this study was to examine the clinical outcomes and efficacy of hip resurfacing arthroplasty (HRA) in patients with osteonecrosis of the femoral head after the failure...
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Trends in Surgical Treatment of Femoral Head Osteonecrosis in South Korea: An Analysis Using Nationwide Claims Database

Park JW, Kim HS, Park S, Kim SH, Lee YK, Koo KH

Background: Osteonecrosis of the femoral head (ONFH) involves young or middle-aged adults, and its incidence is increasing along with increasing use of steroids in the management of organ transplantation and...
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Radiographic changes of mandibular cortical bone in bisphosphonate drug holiday

Lee DH, Seo JI, Song SI, Lee JK

Objectives: There have been few studies to date on the residual effect of bisphosphonate. This study investigated the radiographic changes of mandibular cortical thickness upon bisphosphonate drug holiday. Materials and Methods:...
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MiR-29a-3p Inhibits Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells via Targeting FOXO3 and Repressing Wnt/β-Catenin Signaling in Steroid-Associated Osteonecrosis

Wang C, Zhu M, Yang D, Hu X, Wen X, Liu A

Background and Objectives: This study was to investigate the role of microRNA-29a-3p (miR-29a-3p) in human bone marrow mesenchymal stem cells (hBMSCs), and its relationship with steroid-associated osteonecrosis. Methods and Results: The...
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Epidemiology and risk factors associated with avascular necrosis in patients with autoimmune diseases: a nationwide study

Tsai HL, Chang JW, Lu JH, Liu CS

Background/Aims: Avascular necrosis (AVN) is a clinical condition characterized by the death of bone components due to interruption in the blood supply. This study aimed to investigate the epidemiology and...
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IL-34 Aggravates Steroid-Induced Osteonecrosis of the Femoral Head via Promoting Osteoclast Differentiation

Wang F, Min HS, Shan H, Yin F, Jiang C, Zong Y, Ma X, Lin Y, Zhou Z, Yu X

IL-34 can promote osteoclast differentiation and activation, which may contribute to steroidinduced osteonecrosis of the femoral head (ONFH). Animal model was constructed in both BALB/c and IL-34 deficient mice to...
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Human Umbilical Cord Mesenchymal Stem Cells Improve the Necrosis and Osteocyte Apoptosis in Glucocorticoid-Induced Osteonecrosis of the Femoral Head Model through Reducing the Macrophage Polarization

Tian G, Liu C, Gong Q, Yu Z, Wang H, Zhang D, Cong H

Background and Objectives: Apoptosis is an outstanding determinant of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH). Human umbilical cord mesenchymal stem cells (hUC-MSCs) have been demonstrated to be associated...
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Risk Factors and Outcomes Associated with Intraoperative Fractures during Short-Stem Total Hip Arthroplasty for Osteonecrosis of the Femoral Head

Malhotra R, Gupta S, Gupta V, Manhas V

Background: Young age in osteonecrosis of the femoral head (ONFH) demands bone-preserving, short-stem arthroplasty. Several designs including neck-preserving stems and neck-resecting, shortened, standard stems are classified as short stems. There...
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Closed extensor tendon rupture caused by Kienböck disease: a case report

Choi JY, Cha WJ, Jung ER, Seo BF, Jung SN

Kienböck disease, a rare disease that can cause chronic pain and motor dysfunction, occurs due to avascular necrosis of the lunate bone, which leads to dislocation of the carpal bone....
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Reconstruction of mandibular defects in osteoradionecrosis and medication-related osteonecrosis of the jaw using fibula free flap and management of postoperative wound infections

Oh H, Kwon D, Ahn J, Paeng J

Background Complications from osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) include oro-cutaneous fistulas, necrotic bone exposure, soft-tissue defects, and pathologic fractures. The fibula free flap (FFF) is a common...
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Efficacy of hyaluronic acid, absorbable collagen sponge, and their combination in minimizing bisphosphonate-related osteonecrosis of the jaws (BRONJ) after dental extraction: a preliminary animal histomorphometric study

Sarkarat F, Modarresi A, Riyahi A, Mortazavi P, Tabandeh F, Rakhshan V

Introduction There is no study on the effectiveness of hyaluronic acid (HA) placement either with or without absorbable collagen sponge (ACS) in reducing or preventing bisphosphonate-related osteonecrosis of the jaws (BRONJ)....
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Spontaneous bone regeneration in resected non-continuous mandible due to medication-related osteonecrosis of the jaw

Esen A, Gurses G, Akkulah S

Few cases of spontaneous bone regeneration after extensive resection of the jaw bone have been reported, but it is more common in young adults or children. In this case, we...
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