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More Effective Way to Perform Complete Percutaneous Vertebroplasty for Patients in Kummell’s Disease: A Case Report

Yoo SH, Chae JS, Lee M, Kang BK, Park HS, Kim WJ

An 84-year-old woman visited our pain clinic with complaints of low back pain and severe radiating pain in the right lower extremity during walking. The patient demonstrated subacute compression fracture...
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Updated Guide to the Treatment of Osteonecrosis of the Femoral Head

Yeom JU, Kim YS, Koo KH

Osteonecrosis of the femoral head usually affects young or middle-aged adults and frequently leading to femoral head collapse and hip arthritis. This review reports the updated treatments of the disease.
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Osteonecrosis of the Femoral Head: an Updated Review of ARCO on Pathogenesis, Staging and Treatment

Hines JT, Jo WL, Cui Q, Mont MA, Koo KH, Cheng EY, Goodman SB, Ha YC, Hernigou P, Jones LC, Kim SY, Sakai T, Sugano N, Yamamoto T, Lee MS, Zhao D, Drescher W, Kim TY, Lee YK, Yoon BH, Baek SH, Ando W, Kim HS, Park JW

Non-traumatic osteonecrosis of the femoral head (ONFH) usually affects adults younger than 50 years and frequently leads to femoral head collapse and subsequent arthritis of the hip. It is becoming more...
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A critical assessment of the medication-related osteonecrosis of the jaw classification in stage I patients: a retrospective analysis

Ristow O, Hürtgen L, Moratin J, Smielowski M, Freudlsperger C, Engel M, Hoffmann J, Rückschloß T

Objectives: It is unclear whether the extent of intraoral mucosa defects in patients with medication-related osteonecrosis of the jaw indicates disease severity. Therefore, this study investigated whether mucosal lesions correlate...
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Mesenchymal stem cells in the treatment of osteonecrosis of the jaw

Nifosì G, Nifosì L, Nifosì AF

Medication-related osteonecrosis of the jaw (MRONJ) has recently associated to the increase in antiresorptive and anti-angiogenic drugs prescriptions in the treatment of oncologic and osteoporotic patients. The physiopathogenesis of MRONJ...
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Culture-Expanded Autologous AdiposeDerived Mesenchymal Stem Cell Treatment for Osteonecrosis of the Femoral Head

Yoon PW, Kang JY, Kim CH, Lee SJ, Yoo JJ, Kim HJ, Kang SK, Min JH, Yoon KS

Background: Outcomes of traditional treatment for osteonecrosis of the femoral head (ONFH) are not always satisfactory. Hence, cell-supplementation therapy has been attempted to facilitate necrotic-tissue regeneration. Adipose-derived mesenchymal stem cell...
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ARCO Consensus on the Pathogenesis of Non-traumatic Osteonecrosis of the Femoral Head

Cui Q, Jo WL, Koo KH, Cheng EY, Drescher W, Goodman SB, Ha YC, Hernigou P, Jones LC, Kim SY, Lee KS, Lee MS, Lee YJ, Mont MA, Sugano N, Taliaferro J, Yamamoto T, Zhao D

Osteonecrosis of the femoral head (ONFH) is a devastating disease frequently leading to femoral head collapse and hip arthritis. Specifically, non-traumatic ONFH primarily affects young and middle-aged adults. Although compromised...
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Antiresorptive medication in oncology: the clinical and dental profile of patients in a reference center

Ferreira VHC, Kemp AT, Vendruscolo J, Sassi LM, Schussel JL

Objectives: The aim of this study was to evaluate the profile of patients on antiresorptive therapies for cancer treatment and assess presence of oral lesions, oral hygiene status, and knowledge...
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Effect of Human Umbilical Cord Matrix-Derived Mesenchymal Stem Cells on Bisphosphonate-Related Osteonecrosis of the Jaw

Yang G, Kim YN, Kim H, Lee BK

BACKGROUND: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe sequela caused by bisphosphonates (BPs), which are widely used to treat osteoporosis or other malignancies. However, the mechanism underlying BRONJ...
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Treatment of Kümmell’s disease following the occurrence of osteoporotic vertebral compression fracture

Park SJ

Background: The incidence of osteoporotic vertebral compression fracture (OVCF) is increasing with the increase in the elderly population. Kümmell’s disease following OVCF occurrence is not a rare complication and is...
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Review and Update of the Risk Factors and Prevention of Antiresorptive-Related Osteonecrosis of the Jaw

Kim HY

Antiresorptive-related osteonecrosis of the jaw (ARONJ) is a rare but serious adverse event of bisphosphonate or denosumab administration; it is associated with severe pain and a deteriorated quality of life....
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Pediatric Femoral Neck Fracture

Han JH, Park H

Pediatric femoral neck fracture is an uncommon injury with a high complication rate, regardless of the appropriate diagnosis and management. The bony anatomy and blood supply of the proximal femur...
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Avascular Necrosis of the Hip in Primary Care

Baharum NN, Ariffin F, Hanafiah M, Sulaiman SH

Avascular necrosis, or osteonecrosis of the femoral head, is a debilitating condition which leads to the destruction of the hip joint due to an interruption in the blood supply to...
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The effect of melatonin on prevention of bisphosphonate-related osteonecrosis of the jaw: an animal study in rats

Yadegari A, Aminzadeh A, Seyyedkhamesi S, Aminian M

Objectives: Melatonin induces human stem cells, converts pre-osteoblasts to mature osteoblasts, and reduces the duration of this transition. However, melatonin itself prevents activation of osteoclasts. Here, we evaluate the role...
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Regenerative effect of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) after sequestrectomy of medication-related osteonecrosis of the jaw (MRONJ)

Min SH, Kang NE, Song SI, Lee JK

Objectives: Beyond the original application approved by the U.S. Food and Drug Administration, recombinant human bone morphogenetic protein- 2 (rhBMP-2) is used for medication-related osteonecrosis of the jaw (MRONJ) treatment...
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Core Decompression Combined with Implantation of Autologous Bone Marrow Concentrate with Tricalcium Phosphate Does Not Prevent Radiographic Progression in Early Stage Osteonecrosis of the Hip

Hernandez , Nuñez JH, Sallent A, Gargallo-Margarit A, Gallardo-Calero I, Barro V

Background: Untreated osteonecrosis of the femoral head ultimately leads to secondary coxarthrosis. The aim of this study was to determinate if the core decompression of the femoral head combined with...
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Enhancement of peri-implant bone formation via parathyroid hormone administration in a rat model at risk for medication-related osteonecrosis of the jaw

Park JY, Heo HA, Park S, Pyo SW

Purpose: Dental implant-associated medication-related osteonecrosis of the jaw has been frequently reported in patients administered bisphosphonates (BPs) to prevent osteoporosis. The aim of this study was to investigate the effect...
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The effect of bisphosphonate discontinuation on the incidence of postoperative medication-related osteonecrosis of the jaw after tooth extraction

Kang SH, Park SJ, Kim MK

OBJECTIVES: The discontinuation of bisphosphonate (BP) treatment before tooth extraction may induce medication-related osteonecrosis of the jaw (MRONJ). Whether the long-term discontinuation of BP treatment before tooth extraction affects the...
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Implant Related MRONJ – A Case of Partial Mandibulectomy in the Medically Compromised Elderly Patient

Jung CH, Park KS

The aim of this case report is to present the possibility of development of osteonecrosis around implant under load in a patient taking antiresorptive agent. A 78-year-old female complained of...
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Radiologic results of additional single screw fixation with lateral locking plate after hybrid closed-wedge high tibial osteotomy

Hiraoka N, Nakagawa S, Otakara E, Inoue H, Takahashi K, Arai Y

Background: Hybrid closed-wedge high tibial osteotomy (hybrid CWHTO) is an effective surgical treatment for medial compartment osteoarthritis of the knee. Our study investigated whether the combination of a lateral locking...
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