Brain Tumor Res Treat.  2014 Oct;2(2):119-123. 10.14791/btrt.2014.2.2.119.

Hemorrhagic Recurrence in Diffuse Astrocytoma without Malignant Transformation

• Baek HJ
• Kim SM
• Chung SY
• Park MS

• KMID: 2134283
• DOI: http://doi.org/10.14791/btrt.2014.2.2.119

Abstract

Although uncommon, hemorrhage can be a complication of low grade glioma with an unfavorable prognosis such as transformation to higher grade glioma. To our knowledge, hemorrhagic recurrence of World Health Organization Grade II, diffuse astrocytoma without malignant transformation has not been reported. Thus, we report a case of diffuse astrocytoma with hemorrhagic recurrence without malignant transformation. The patient had undergone craniotomy and tumor removal 7 years previously. Annual follow-up MRIs had shown evidence of slow tumor recurrence. With the sudden onset of seizure, the patient was diagnosed as hemorrhagic recurrence and underwent second tumor removal highly suspecting malignant change into higher grade glioma. Histopathology confirmed diffuse astrocytoma without malignant changes. As the patient's postoperative condition was excellent, we plan to withhold chemotherapy and radiation therapy for use as a later treatment option.

Keyword

Astrocytoma; Glioma; Recurrence

MeSH Terms

Astrocytoma*
Craniotomy
Drug Therapy
Follow-Up Studies
Glioma
Hemorrhage
Humans
Magnetic Resonance Imaging
Prognosis
Recurrence*
Seizures
World Health Organization