J Korean Med Sci.
2014 Aug;29(8):1090-1093. 10.3346/jkms.2014.29.8.1090.
Follow-up Testing of Interferon-Gamma Release Assays Are Useful in Ankylosing Spondylitis Patients Receiving Anti-Tumor Necrosis Factor Alpha for Latent Tuberculosis Infection
- Affiliations
-
- 1Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
- 2Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea. thkim@hanyang.ac.kr
- 3Department of Orthopaedic Surgery, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
- KMID: 2129603
- DOI: http://doi.org/10.3346/jkms.2014.29.8.1090
Abstract
- We evaluated the utility of follow-up interferon-gamma release assays (IGRAs) for the diagnosis of reactivation of latent tuberculosis infection (LTBI) or new tuberculosis in ankylosing spondylitis (AS) patients receiving anti-tumor necrosis factor alpha (anti-TNFalpha). The study participants (n=127) had a negative IGRA screening before receiving anti-TNFalpha and were evaluated by follow-up IGRA. We retrospectively examined data of the subjects according to age, gender, tuberculosis prophylaxis, concomitant medications, IGRA conversion and anti-TNFalpha, including type and treatment duration. The median duration of anti-TNFalpha was 21.5 months, and the median age was 35.3 yr. Of the 127 patients, IGRA conversion was found in 10 patients (7.9%). There was no significant variation between IGRA conversion rate and any risk factors except for age. IGRA conversion rate was not significantly different between AS and rheumatoid arthritis (P=0.12). IGRA conversion was observed in AS patients receiving anti-TNFalpha in Korea. A follow-up IGRA test can be helpful for identifying LTBI or new tuberculosis in AS patients receiving anti-TNFalpha.
Keyword
MeSH Terms
-
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal/*adverse effects/*therapeutic use
Antirheumatic Agents/adverse effects/therapeutic use
Female
Follow-Up Studies
Humans
Interferon-gamma/*blood
Latent Tuberculosis/*blood/*chemically induced/diagnosis
Longitudinal Studies
Male
Middle Aged
Prognosis
Reproducibility of Results
Sensitivity and Specificity
Spondylitis, Ankylosing/blood/*drug therapy
Treatment Outcome
Tumor Necrosis Factor-alpha/antagonists & inhibitors
Antibodies, Monoclonal
Antirheumatic Agents
Interferon-gamma
Tumor Necrosis Factor-alpha
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Diagnosis and Treatment of Latent Tuberculosis Infection due to Initiation of Anti-TNF Therapy
- Occurrence of tuberculous pleurisy associated with infliximab therapy
- Clinical Applications of Interferon-gamma Release Assays
- Diagnosis and Treatment of Latent Tuberculosis Infection in Patients with Inflammatory Bowel Diseases due to Initiation of Anti-Tumor Necrosis Factor Therapy
- Serial Interferon-gamma Release Assays for the Diagnosis of Latent Tuberculosis Infection in Patients Treated with Immunosuppressive Agents
