J Korean Ophthalmol Soc.  2007 Mar;48(3):438-444.

The Amniotic Membrane Transplantation in Corneal Perforation due to Mooren's Ulcer

• Kim MJ
• Wee WR
• Lee JH
• Kim MK

Abstract

PURPOSE: To report patients with corneal perforation with Mooren's ulcer treated successfully with amniotic membrane transplantation and cryotherapy.
METHODS
We performed conjunctival recession, permanent amniotic membrane transplantation, cryotherapy, amniotic membrane patch to treat corneal perforation associated with severe inflammatory Mooren's ulcer of 4 eyes in 3 patients. We investigated the interval of absence of inflammation, reepithelization over grafted amniotic membrane, and restoration of visual acuity.
RESULTS
The perforated corneal lesion was sealed successfully by the amniotic membrane in 4 eyes. The complete reepithelization over grafted amniotic membrane was achieved 21+/-2.7 days and complete remission was achieved 94+/-13.0 days after surgery. There was no recurrence in 3 eyes during 21+/-2.7 months. A patient who recurred inflammatory impending corneal perforation underwent limbal transplantation with amniotic membrane re-transplantation, which resulted in remission after 13 months. All 3 eyes restored visual acuity Except one who developed cataract.
CONCLUSIONS
Amniotic membrane transplantation may be useful in treating corneal perforation with active inflammation in Mooren's ulcer.

Keyword

Amniotic membrane transplantation; Corneal perforation; Mooren's ulcer; Reepithelialization

MeSH Terms

Amnion*
Cataract
Corneal Perforation*
Cryotherapy
Humans
Inflammation
Recurrence
Transplants
Ulcer*
Visual Acuity