J Korean Ophthalmol Soc.  2007 Mar;48(3):343-347.

Noninfectious Severe Early Chamber Reaction after Penetrating Keratoplasty

• Lim SJ
• Kim SY
• Kim MS

Abstract

PURPOSE: To report 8 cases of Noninfectious early anterior chamber reaction after penetrating keratoplasty (PKP), and to review relevant literature.
METHODS
Retrospectively, we reviewed medical records of 8 patients who had undergo PKP from March 2001 to May 2004, associated with early severe chamber reaction.
RESULTS
Preoperative diagnosis are corneal opacity (4 cases), keratoconus (2 cases), corneal ectasia after LASIK (1 case) and graft failure (1 case). Although they didn't show severe chamber reaction at first day after surgery, the anterior chamber reaction with cornea edema and decreased visual acuity had increased with time. We didn't give the additional treatment except increasing the number of instillation of topical steroid. The inflammation was improved within a week and the complete resolution was achieved during the follow-up in all cases. In all cases posterior synechia and anterior subcapsular opacity were found.
CONCLUSIONS
It seems reasonable to conclude that a single common etiologic factor could not responsible for this syndrome. Non-infectious inflammation developing upon PKP may be caused by a multifactorial process like increased IOP, toxic anterior segment syndrome form surgical trauma or hypersensitivity reaction et al and viscoelastics effect.

Keyword

Chamber reaction; Inflammation; Penetrating keratoplasty

MeSH Terms

Anterior Chamber
Cornea
Corneal Opacity
Diagnosis
Dilatation, Pathologic
Edema
Follow-Up Studies
Humans
Hypersensitivity
Inflammation
Keratoconus
Keratomileusis, Laser In Situ
Keratoplasty, Penetrating*
Medical Records
Retrospective Studies
Transplants
Visual Acuity