J Korean Ophthalmol Soc.
2003 Oct;44(10):2222-2227.
Corneal Edema Induced by Balafilcon A Contact Lens in Rabbits
- Affiliations
-
- 1Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Korea.
- 2Department of Ophthalmology, Guro Hospital, Korea University College of Medicine, Korea. hongjw@kumc.or.kr
- 3Department of Ophthalmology, Anam Hospital, Korea University College of Medicine, Korea.
Abstract
- PURPOSE
To compare the increase of corneal thickness by Balafilcon A (PureVision(R)) with that by HEMA hydrogel in rabbits. METHODS: 15 eyes of New Zealand white rabbits were divided into three groups. Each group was as follows: Group 1 recieved tasorraphy without contact lens insertion, group 2 had PureVision(R) lens insertion with tasorraphy and group 3 had New hypa day(R) lens insertion with tasorrhaphy. After anterior segment examination, tasorrhaphy was performed in group 1 and corneal thickness was measured at 24 and 48 hours. Five PureVision lenses were applied to left corneas of group 2 and transient tasorrhaphy was performed. After 24 and 48 hours, corneal thickness was measured. Same procedure was made in group 3 by applying five New hypa day(R) lenses on left eyes. Anterior segment was reexamined with slit lamp at 24 and 48 hours in all three groups.
RESULTS
Baseline corneal thickness showed no statistical difference among three groups (p>0.05). At 24 hours, the corneal thickness of group 3 (New hypa day(R) lens inserted) increased significantly than that of the other groups (p<0.05). At 48 hours, the corneal thickness of group 2 and 3 increased significantly than group 1 (p<0.05), but there was no statistical difference between two groups (p>0.05).
CONCLUSIONS
Balafilcon A contact lens which has high oxygen transmissibility of silicone with high water content of hydrogel, induce less corneal swelling than conventional extended wear contact lens, HEMA hydrogel in short-term period. However long-term evaluation about Balafilcon A contact lens is required to get more data on corneal swelling and complications after long-term wearing.
