Chonnam Med J.  2002 Jun;38(2):99-106.

Effect of Centrally-administered DOI, a 5-HT2 Receptor Agonist, on the Regulation of Rabbit Renal Nerve Activities

• Lim YC
• Kim HJ
• Baik YH

Abstract

Centrally-administered DOI [1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane HCl], a selective 5-HT2 agonist, has been observed to elicit antidiuresis and antinatriuresis in rabbits. Renal nerves has been suggested to be closely related with this renal effects. This study was therefore carried out to clarify the role of central 5-HT2 receptors by observing the influence of centrally-administered selective 5-HT2 agonist and antagonist on renal nerve activity (RNA). Intracerebroventricular (icv) DOI 100 microgramkg, a dose which produced the most pronounced antidiuresis, elicited significant increase of RNA right after drug administration and reached maximal increase at 5 min, accompanying significant increase of arterial blood pressure and decrease of heart rate. This significant increase of RNA was observed until 40 to 60 min after the administration. Intravenous DOI 100 microgramkg did not evoked any particular RNA responses unlike icv DOI and did not affect blood pressure and heart rate. The potentiating effect of centrally-administered DOI on RNA was significantly blocked by ketanserin, a selective 5-HT2 antagonist, pretreatment. These results suggest that central 5-HT2 receptors mediates the increase of RNA.

Keyword

Centrally-administered; Renal nerve activity; DOI; 5-HT2 Receptors

MeSH Terms

Arterial Pressure
Blood Pressure
Heart Rate
Ketanserin
Rabbits
RNA
Serotonin 5-HT2 Receptor Agonists
Serotonin 5-HT2 Receptor Antagonists
Ketanserin
RNA
Serotonin 5-HT2 Receptor Agonists
Serotonin 5-HT2 Receptor Antagonists