Korean J Dermatol.  1999 Nov;37(11):1576-1582.

Clinicopathologic Studies of 7 Cases with Cutaneous Metastatic Carcinomas from Lung Cancers

• Jeong SW
• Lee SW
• Chun JH
• Cha SH
• Jeong ET
• Park SD

Abstract

BACKGROUND: Cancer that tends to metastasize to other internal organs also involves the skin with various clinical features.
OBJECTIVE
We studied the clinical and histopathological findings of metastatic skin cancer and primary lung cancer.
METHODS
We reviewed the clinical features and histopathological findings in 7 patients with metastatic skin cancer from the lung cancer. We performed routine hematoxylin-eosin stain and immunohistochemical staining with monoclonal antibody to cytokeratin, neuron specific enolase, S-100, leukocyte common antigen, and epithelial membrane antigen using the formalin-fixed paraffin embedded skin tissue of cutaneous metastatic and primary lung cancer.
RESULTS
All patients are men ranging from 44 to 72 years in age(mean, 63.0 years). Cutaneous lesions were nodule, tumor, and sclerotic plaque. Skin lesions appeared on all parts of body. The neck, chest, and scalp were the most common locations of metastases. Pathologic findings were squamous cell carcinoma in 5 patients, adenosquamous cell carcinoma in 2 patients. We found some different immunophenotypes in cutaneous metastatic lesion and lung cancer. Mean survival time from the diagnosis of lung cancer was 10.4 months, and 8.4 months from the diagnosis of skin metastasis.
CONCLUSION
We conclude that patients with cutaneous metastasis of lung cancer reflect progressive, terminal stage, and poor prognosis of the disease.

Keyword

Lung cancer; Skin metastasis

MeSH Terms

Antigens, CD45
Carcinoma, Squamous Cell
Diagnosis
Humans
Keratins
Lung Neoplasms*
Lung*
Male
Mucin-1
Neck
Neoplasm Metastasis
Paraffin
Phosphopyruvate Hydratase
Prognosis
Scalp
Skin
Skin Neoplasms
Survival Rate
Thorax
Antigens, CD45
Keratins
Mucin-1
Paraffin
Phosphopyruvate Hydratase