Korean J Dermatol.  1997 Oct;35(5):931-939.

Clinical and Histopathological Observations of Actinic Keratoses in Korea

Affiliations
  • 1Department of Dermatology, Dr. Soo-Il Chun's Skin Clinic, Korea.
  • 2Department of Dermatology, Korea University, Korea.
  • 3Department of Dermatology, Catholic University Medical College, Korea.
  • 4Department of Dermatology, Kyungpook National University, Korea.
  • 5Department of Dermatology, Kyung Hee Univerisity, Korea.
  • 6Department of Dermatology, Kosin Medical College, Korea.
  • 7Department of Dermatology, Seoul National University, Korea.
  • 8Department of Dermatology, Yonsei University College of Medicine, Korea.
  • 9Department of Dermatology, University of Ulsan, Korea.
  • 10Department of Dermatology, Inje Medical College, Korea.
  • 11Department of Dermatology, Inha University, Korea.
  • 12Department of Dermatology, Chonnam National University, Korea.
  • 13Department of Dermatology, Hallym University, Korea.

Abstract

BACKGROUND: Although actinic keratoses is the most common precancerous cutaneous lesion, there has been no clinical and histopathological study about actinic keratoses in Korea.
OBJECTIVE
Our purpose was to carry out a clinical and histopathological study about actinic keratoses in Korea.
METHODS
158 patients, diagnosed with actinic keratoses from 1987 to 1995 in Korea, were analyzed clinically and histopathologically.
RESULTS
1. The ratio of males to females was 1:2.4 and the most frequent age groups were the 6th(29.1%) and 7th decade(33.5%). 2. The duration of the lesions was more than 1 year in most cases. 3. The most commonly involved sites were the face, in which the cheek, nose and forehead were the most common sites. 4. Clinically, the size of the lesions was less than 1cm in many cases(66.8%). The color was erythematous in 57.9%, brownish in 26.7%, and dark brownish in 15.3%. Crust and scale were noted in 28.7% and 25.2%, respectively. In 4% of patients, cutaneous horn also was noted. 5. Squamous cell carcinoma was associated with actinic keratoses in 5.7%, basal cell carcinoma in 3.2%, and keratoacanthoma in 1.3%. 6. Histopathologically, hypertrophic types of actinic keratoses were noted in 25.0%, atrophic types in 21.3%, hypertrophic and atrophic types in 18.1%, bowenoid types in 17.6%, acantholytic types in 13.3%, and pigmented types in 4.7%. 7. The most commonly used methods of treatment for actinic keratoses were cryotherapy, surgical excision, 5 FU ointment, and electrodesiccation with good effect.
CONCLUSION
Actinic keratoses in Koreans was present on the face most commonly over 50 years of age. It showed a more frequent incidence in females than males. The clinical course of the lesions was chronic and the association with other cutaneous malignancies was noted to be less than 6%. The various histopathological types were noted, including hypertrophic, atrophic, hypertrophic and atrophic, bowenoid, acantholytic, and pigmented. The most commonly used methods of treatment. for actinic keratoses were cryotherapy, surgical excision, 5-FU ointment, and electrodesiccation.

Keyword

Actinic keratosis

MeSH Terms

Actins*
Animals
Carcinoma, Basal Cell
Carcinoma, Squamous Cell
Cheek
Cryotherapy
Female
Fluorouracil
Forehead
Horns
Humans
Incidence
Keratoacanthoma
Keratosis, Actinic*
Korea*
Male
Nose
Actins
Fluorouracil
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