Korean J Thorac Cardiovasc Surg.  1998 May;31(5):531-535.

Heterotopic Heart Transplantation in the Rat Model

• Jung WS
• Jun YB
• Jeon SH
• Kim H
• Lee CB
• Kim YH
• Jee HO
• Suh JK
• Kong G

Abstract

In 1964, Abbott and Colleagues published the world's first heterotopic heart transplantation technique in the rat. Their method established circulation by end-to-end anastomoses of the graft's aorta and pulmonary artery to the recipient's abdominal aorta and Inferior Vena Cava (IVC), respectively. In 1966, Tomita et al altered Abbott's technique by employing end-to-side rather than end-to-end anastomoses, thus eliminating the hind leg paralysis that sometimes resulted from Abbott's technique. In order to prevent postsuture hemorrhage (since 7-0 silk suture was the finest available at that time), Tomita's aortic anastomosis was done with double up-and-down continuous suture technique. A single layer continuous anstomosis effected the pulmonary artery-IVC anastomosis. The availability of Nylon monofilament suture made it possible for Ono and Lindsey to use a single layer suture technique for the aortic end-to-side anastomosis in their modified rat heart transplantation. We observed survival time between control group and Immunosuppression (Cyclosporine administration, 10mg/Kgx4 times postoperatively) group after heterotopic heart transplantation in the rat model. The cyclosporine adminstration group survived longer than the control group, thus we concluded that cyclosporine was based on Immunosuppressive drugs.

Keyword

Heart transplantation; Allograft; Immunosuppression

MeSH Terms

Allografts
Animals
Aorta
Aorta, Abdominal
Cyclosporine
Heart Transplantation*
Heart*
Hemorrhage
Immunosuppression
Leg
Models, Animal*
Nylons
Paralysis
Pulmonary Artery
Rats*
Silk
Suture Techniques
Sutures
Vena Cava, Inferior
Cyclosporine
Nylons
Silk