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XPERNATO-TOX: an Integrated Toxicogenomics Knowledgebase

Woo JH, Kim HE, Kong G, Kim JH

  • KMID: 2166193
  • Genomics Inform.
  • 2006 Mar;4(1):40-44.
Toxicogenomics combines transcriptome, proteome and metabolome profiling with conventional toxicology to investigate the interaction between biological molecules and toxicant or environmental stress in disease caution. Toxicogenomics faces the problems of...
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Increased Neuronal and Glial Poly (ADP-Ribose) Polymerase Immunoreactivity in the Brain of Sporadic Amyotrophic Lateral Sclerosis

Kim SH, Engelhardt JI, Kim JH, Kong G, Appel SH

  • KMID: 2137972
  • J Korean Neurol Assoc.
  • 2002 Nov;20(6):682-693.
BACKGROUND: Over activation of the DNA repairing enzyme, poly (ADP-ribose) polymerase (PARP) in response to oxidative damage of DNA appears to play a role in cellular death in neurodegenerative diseases....
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Poly (ADP-Ribose) Polymerase immunoreactivity in Motor Neurons and Astrocytes in the Spinal Cord of Sporadic Amyotrophic Lateral Sclerosis Patients

Kim SH, Henkel JS, Kim JH, Kim MH, Engelhardt JI, Siklos L, Kong G, Appel SH

  • KMID: 2137971
  • J Korean Neurol Assoc.
  • 2002 Nov;20(6):668-681.
BACKGROUND: The evidence for increased oxidative stress and DNA damage in amyotrophic lateral sclerosis (ALS) prompted studies to determine if the expression of poly (ADP-ribose) polymerase (PARP) is increased in...
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Role of Immune-Inflammatory Mechanisms in Alzheimer's Disease and Other Degenerative Diseases

Kim SH, Kong G

  • KMID: 2137959
  • J Korean Neurol Assoc.
  • 2002 Nov;20(6):575-584.
Recent studies suggest that alterations of the immune-inflammatory system contribute to the pathogenesis of Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis (ALS). Neuroinflammatory response initiated by innate...
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Genetic Polymorphism of Xenobiotics Metabolizing Enzymes and Individual Susceptible Genes to Colorectal Cancer Patients in Korea

Lee HW, Kim MS, Jung PJ, Kim HJ, Kong G, Chun H

  • KMID: 2025764
  • J Korean Soc Coloproctol.
  • 2002 Aug;18(4):205-215.
Individual susceptibility to cancers may result from several factors including differences in xenobiotics metabolism, DNA repair, altered oncogenes and suppressor genes, and environmental carcinogen exposures. To determine the frequencies of...
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The roles of inducible nitric oxide synthase expression in pancreatic cancer

Lee YW, Lee KT, Ahn BH, Park DI, Lee JK, Paik SW, Rhee JC, Choi KW, Kim WS, Kim EK, Kong G

  • KMID: 1601714
  • Korean J Med.
  • 2001 Dec;61(6):597-605.
BACKGROUND: The finding of frequent inducible nitric oxide synthase (iNOS) expression in human cancer indicates that nitric oxide has a pathological role in tumor progression. Increased expression of iNOS in...
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Inhibition of rac1 Reduces PDGF-induced Reactive Oxygen Species and Proliferation in Vascular Smooth Muscle Cells

Kong G, Lee S, Kim KS

In vascular smooth muscle cells, reactive oxygen species (ROS) were known to mediate platelet-derived growth factor (PDGF)-induced cell proliferation and NADH/NADPH oxidase is the major source of ROS. NADH/NADPH oxidase...
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The Differences Between Cyclosporine and Tacrolimus in the Generation of ROS and Extracellular Matrix Accumulation in Primary Cultured Human Mesangial Cells

Lee SK, Lee SJ, Kim HJ, Kong G, Kahng KW, Kang CM

  • KMID: 2079155
  • Korean J Nephrol.
  • 2001 Mar;20(2):187-197.
OBJECTIVE: Cyclosporine(CsA) and tacrolimus, albeit different in structure, exert immunosuppressive effect by similar mechanism. Although most of clinical manifestations, including nephrotoxicity, are similar in the patients using these drugs, there...
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Effect of Transforming Growth Factor-beta1 on Expressions of Epidermal Growth Factor and Transforming Growth Factor-alpha in DU145 Androgen-Independent Prostate Cancer Cells

Shin KY, Kong G, Choi HS, Lee JJ, Lee TY

  • KMID: 2292443
  • Korean J Urol.
  • 2001 Jan;42(1):40-46.
PURPOSE: This study was designed to identify the possible mechanism of insensitivity of DU145 prostate cancer cells to the transforming growth factor (TGF)-beta1-mediated growth inhibition. MATERIALS AND METHODS: DU145 cells were...
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The Effects of Cyclosporine on the Generation of ROS and Extracellular Matrix Accumulation in Cultured Human Mesangial Cells

Chae HK, Lee SJ, Kim HJ, Kong G, Kahng KW, Kang CM

  • KMID: 1989887
  • Korean J Nephrol.
  • 2000 Nov;19(6):1024-1032.
OBJECTIVE: Treatment with cyclosporine(CsA) for a long-term period may induce renal glomerulosclersosis and interstitial fibrosis. Reactive oxygen species(ROS) seems to be involved in the process of glomerulosclersosis and interstitial fibrosis....
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Genetic susceptibilities of cytochrome P450 1A1, 2E1, and N-acetyltransferase 2 to the risks for Korean head and neck cancer patients

Lee YS, Kim TG, Woo SS, Shim KS, Kong G

  • KMID: 2009658
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2000 Jul;22(4):373-382.
Individual genetic susceptibilities to cancers may result from several factors including differences in xenobiotics metabolism to chemical carcinogens, DNA repair, altered oncogenes and suppressor genes, and environmental carcinogen exposures. Among...
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Effects of Human Recombinant Interferon-Gamma and Tumor Necrosis Factor-Alpha on Expressions of Matrix Metalloproteinases and Their Activity Human Bladder Cancer Cell Lines

Moon HS, Shin KY, Kong G, Kim HJ, Lee JJ, Woo YN

  • KMID: 1646784
  • Korean J Urol.
  • 2000 Jun;41(6):695-702.
No abstract available.
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Genetic Alterations of Human Oral Cancers Using Comparative Genomic Hybridization

Lee MR, Shim KS, Lee YS, Woo SS, Kong G

  • KMID: 1543522
  • J Korean Assoc Oral Maxillofac Surg.
  • 2000 Jun;26(3):245-253.
The development and progression of oral cancer is associated with an accumulation of multiple genetic alterations through the multistep processes. Comparative genomic hybridization(CGH), newly developed cytogenetic and molecular biologic technique,...
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The Frequency of CD34 and CD34 CD38 Hematopoietic Stem/Progenitor Cells in the Cord Blood and Adult Peripheral Blood

Im HJ, Ahn SY, Lee H, Kong G

  • KMID: 1979917
  • Korean J Pediatr Hematol Oncol.
  • 2000 Apr;7(1):1-8.
PURPOSE: The umbilical cord blood has been considered as an alternative source of hematopoietic stem cells for transplantation. The CD34+ is known as a common stem cell antigen and...
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Skin Tissue Changes Following Thermal Injury in the Paralysed Lower Limb of Spinal Injured Rats

Kim MJ, Sung IY, Han SH, Kong G

  • KMID: 2323333
  • J Korean Acad Rehabil Med.
  • 1999 Dec;23(6):1083-1094.
OBJECTIVE: To prove that the skin of paralysed limb of spinal injured rat is more susceptible to a thermal injury than control, and to find out that the possible relating...
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Genetic Polymorphism of Cytochrome P4501A1 Exon 7 and Glutathione S-Transferase M1 in the Head and Neck Squamous Cell Carcinoma Patients

Ko KM, Ahn KS, Tae K, Lee SH, Kong G

  • KMID: 1977721
  • Korean J Otolaryngol-Head Neck Surg.
  • 1999 Nov;42(11):1405-1412.
BACKGROUND AND OBJECTIVES: An individual difference in susceptibility to chemically induced carcinomas is in part ascribed to genetic differences of metabolic activity of environmental procarcinogens. The cytochrome P450 family (CYPs)...
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Microsatellite Instability and Its Clinicopathologic Significance in Korean Gastric Cancer Patients

Sohn TS, Lee KS, Choi SH, Kim YI, Cho YH, Kong G

  • KMID: 2206456
  • J Korean Surg Soc.
  • 1999 Apr;56(4):539-547.
BACKGROUND: Genomic instability has been reported as a novel mechanism of tumorigenesis. Microsatellites are short tandemly repeated nucleotide sequences throughout the human genome. Widespread somatic mutations in these sequences due...
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Genetic Susceptibilities of Cytochrome P4501A1 and Glutathione S-transferase M1 to the Risk for Korean Head and Neck Squamous Cell Carcinoma Patients

Shin CS, Ahn KS, Tae K, Lee HS, Kim HJ, Kong G

  • KMID: 2074355
  • Korean J Otolaryngol-Head Neck Surg.
  • 1999 Feb;42(2):202-208.
BACKGROUND AND OBJECTIVES: Individual genetic susceptibilities to chemical carcinogens have been recognized as a major important host factors in human cancers. The cytochrome P450 family (CYPs) and glutathione-S-transferase (GST) have...
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Status of Bcl-2 expression and Its Relationship to the Other Prognostic Factors in Breast Cancer

Roh GY, Shin DH, Park YL, Shin JH, Kim HD, Kim YS, Han WK, Keum JS, Kim MS, Kong G, Kim MS

  • KMID: 2175307
  • J Korean Cancer Assoc.
  • 1998 Dec;30(6):1131-1139.
PURPOSE: There are several well-established prognostic factors to predict the course of breast cancer. Recently, a new category of genes that control the process of programmed cell death, also called...
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Prognostic Value of the Expression of p53 and bcl-2 in Non-Small Cell Lung Cancer

Yang SC, Yoon HJ, Shin DH, Park SS, Lee JH, Keun JS, Kong G, Lee JD

  • KMID: 2318159
  • Tuberc Respir Dis.
  • 1998 Oct;45(5):962-974.
BACKGROUND: Alteration of p53 tumor suppressor genes is most frequently identified in human neoplasms, including lung carcinoma. It is well known that bcl-2 oncoprotein protects eel]s from apoptosis. Recent studies...
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