Korean J Anat.  2007 Jun;40(2):107-113.

Increased Expressions of eNBC and NHE1 in Ischemic Penumbra after Permanent Middle Cerebral Artery Occlusion

• Jung YW
• Park JS

Abstract

We conducted a chronological and comparative analysis of the levels of the electrogenic Na+/HCO3-cotransporter (eNBC) and Na+/H+ exchanger 1 (NHE1) on ischemic penumbra, using the rat model of permanent middle cerebral artery occlusion (pMCAO). Both eNBC and NHE1 levels were significantly higher in the ischemic penumbra from 3 h to 6 h after focal ischemia than in the sham-operated control group. The enhancement of eNBC and NHE1 production following focal ischemia may contribute to brain cell swelling or damage during ischemic penumbra through intracellular alkalinization and Na+ overload. Therefore, increases of eNBC and NHE1 in ischemic penumbra may play an important role in secondary brain cell damages following permanent focal ischemic insults.

Keyword

Ischemia; Penumbra; eNBC; NHE1

MeSH Terms

Brain
Infarction, Middle Cerebral Artery*
Ischemia
Middle Cerebral Artery*
Models, Animal