Korean J Dermatol.  1997 Aug;35(4):814-818.

A Case of Multiple Histiocytomas in a Healthy Person

Affiliations
  • 1Department of Dermatology, Pusan National University College of Medicine, Pusan, Korea.

Abstract

Epidermolysis bullosa acquisita(EBA) is a rare chronic subepidermal bullous disease wit,h autoantibodies to type VII collagen. Clinically, EBA usually begins after the age of 50 with pruritic vesicle and blister formation often on traumatized skin and leaves atrophic scars and milia. A 48-year-old woman visited our department with a 5 month history of a generalized pruritic blistering eruption that began on the scalp and spread to the face, trunk, extremities, and lip. The biopsy specimen revealed dermoepidermal separation, infiltration of perivascular mononuclear cells. Direct immunofluorescence(DIF) showed positive linear deposition of IgG at the BMZ. Bullous pemphigoid was diagnosed and treated with prednisolone 20-40mg daily. The skin lesions were improved after 2 week. During follow-up, trauma-induced vesicles occurred frequently and healed with remaining malia and scars. The biopsy specimen of trauma induced vesicles revealed subepidermal blisters and inflammatory cell infiltration in the dermis. DIF of perilesional skin showed positive linear deposition of IgG at the BMZ. DIF of salt split skin showed linear IgG deposits on the dermal floor. EBA was confirmed.

Keyword

Bullous pemphgoid; Epidermolysis bullosa acquisita; Salt split skin

MeSH Terms

Autoantibodies
Biopsy
Blister
Cicatrix
Collagen Type VII
Dermis
Epidermolysis Bullosa
Epidermolysis Bullosa Acquisita
Extremities
Female
Follow-Up Studies
Histiocytoma*
Humans
Immunoglobulin G
Lip
Middle Aged
Pemphigoid, Bullous
Prednisolone
Scalp
Skin
Autoantibodies
Collagen Type VII
Immunoglobulin G
Prednisolone
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