A Clinical and Histopathologic Study on Granuloma Pyogenicum

Kim, Jae Sun; Kim, Jong Min; Lee, Eil Soo; Khang, Shin Kwang; Ro, Byung In; Chang, Chin Yo

Abstract

We observed the histopathologic findings of 21 biopsed materials those initial clinical impression was suspected as granuloma pyogenicum. Also we compared the cange in the number of mast cells in the lesion of the granuloma pyogenicum with those in the normal appearing skin by Giemsa stain, and the stainability of mucopolysaccharides in the stromal edema of granuloma pyogenicum lesion with that in the normal appearing skin by Alcian blue-PAS stain. The results were as fallows: The various microscopic diagnoses made in 8 cases, which was clinically granuloma pyogenicurn. These 8 cases were granulation tissue(3), subungual exostosis(1), dermatofibrorna(1), sebaceous epithelioma(l), liporna with granulation tissue(1), and malignant melanoma(1). 2. The number of mast cells in the granuloma pyogenicum lesion were increased (p<0.01), especially in the lesion which showed marked capillary endothelial proliferation, and the amount of mucopolysaccharides was increased in the stromal edema of the granuloma pyogenicum lesion.