Korean J Gynecol Oncol Colposc.  2000 Dec;11(4):397-403.

Expression of c-erbB-2 and Distribution of S-100 Protein Positive Dendritic Cells in Squamous Cell Carcinoma of the Uterine Cervix

• Shin JO
• Choi SD
• SunWoo JG
• Bae DH
• Kim DJ

Abstract

OBJECTIVE: The aim of this study was to assess the relationship between disease progression and expression of c-erbB-2 and S-100 protein positive dendritic cells in Cervical cancer. STUDY DESIGN: Tissues were analyzed from 100 patients. Each of them had invasive carcinoma(44), microinvasive(12), CIS(33), CIN(II) before treatment, c-erbB-2 oncoprotein expression and S-100 protein positive dendritic cell were confirmed by immunohistochemical staining. (Avidin-biotin complex method)
RESULTS
C-erbB-2 immunostaining was significantly associated with disease progression (p<0.05). In case of CIN I, there was not noted stained specimen but in case of invasive carcinoma, 24 cases of stained specimen were noted. S-100 protein positive dendritic cell was not associated with disease progression of cervical carcinoma.(p>0.05)
CONCLUSIONS
According to our results, c-erbB-2 is possible factor in Carcinogenesis of cervical carcinoma with progression of it. and S-100 protein positive dendritic cell was not associated with disease progression of cervical carcinoma.

Keyword

c-erbB-2; S-100 protein; Cervical carcinoma

MeSH Terms

Carcinogenesis
Carcinoma, Squamous Cell*
Cervix Uteri*
Dendritic Cells*
Disease Progression
Female
Humans
S100 Proteins*
Uterine Cervical Neoplasms
S100 Proteins