Korean J Hematol.
2002 May;37(2):147-152.
A Case of Acquired Amegakaryocytic Thrombocytopenia Responding to Immunosuppressive Therapy
- Affiliations
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- 1Department of Internal Medicine, Gachon Medical School, Ghil Medical Center, Inchon, Korea. jhlee@ghil.com
- 2Department of Clinical Pathology, Gachon Medical School, Ghil Medical Center, Inchon, Korea.
Abstract
- Acquired amegakaryocytic thrombocytopenia is a relatively rare bone marrow failure disorder characterized by severe thrombocytopenia associated with a total absence or a marked reduction in the number of bone marrow megakaryocytes. We report a case of acquired amegakaryocytic thrombocytopenia. A 39-year old man admitted our hospital because of gingival bleeding and purpura on the thigh, his initial complete blood cell counts were white blood cell 5.6 103/micro liter hemoglobin 9g/dL, and platelet 1 103/micro liter On the bone marrow study, megakaryocyte was not observed and cytogenetic analysis of marrow was 46, XY, inv(9). (p11q13). Other autoimmune markers were negative. The patient received steroid therapy during 8 weeks, but there was no significant improvement and then he received immunosuppressive therapy with antithymocyte globulin and cyclosporin-A. Thereafter the platelet count increased to 80 103/micro liter, and this level continued for 10 months
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