Korean J Infect Dis.
1998 Dec;30(6):558-563.
Changes in Antibody Titers of Measles, Mumps, Rubella, and Hepatitis B Virus AftEr Bone Marrow Transplantation in Korea: A Preliminary Report
- Affiliations
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- 1Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Abstract
- BACKGROUND
Bone marrow transplantation (BMT) has become a significant treatment modality for hematopoietic and solid organ malignancy. Recipients of BMTs lose immunity to measles-mumps-rubella (MMR) and hepatitis B infections which are preventable with vaccination. There is no consensus regarding a vaccination schedule after BMT and time of vaccination is variable according to each institution. We analyzed sequential changes in antibody titers of MMR and hepatitis B during the first year after BMT in an attempt to identify the time, dose, and needs for revaccination.
METHODS
Total 20 patients with hematologic malignancies were studied. Serum levels of IgG antibodies of MMR and hepatitis B virus (HBV) were determined every three months post-BMT by enzyme immunoassay (EIA), chemical luminescence immunoassay (CLIA) and immunofluorescence assay (IFA).
RESULTS
IgG antibody levels of measles, rubella, HBV were 1:746, 80 85 IU/mL, 214 343 IU/L before BMT, declined to 1:633, 18 11 IU/mL, 4 6 IU/L one year after BMT, respectively. All the antibody levels were still above cut-off value for positive immunity. Mumps antibody titers were 1:62 before BMT, declined to 1:25 significantly from 6 months after BMT, but the antibody level was still above cut-off value.
CONCLUSION
Antibody titers of MMR and hepatitis B decline during the first year after BMT, but the levels are still above cut-off value. Thus, the timing of revaccination should be after the first year post-transplantation. Long-term studies are needed to determine the optimal time for revaccination.
Keyword
MeSH Terms
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Antibodies
Appointments and Schedules
Bone Marrow Transplantation*
Bone Marrow*
Consensus
Fluorescent Antibody Technique
Hematologic Neoplasms
Hepatitis B virus*
Hepatitis B*
Hepatitis*
Humans
Immunization, Secondary
Immunoassay
Immunoenzyme Techniques
Immunoglobulin G
Korea*
Luminescence
Measles*
Mumps*
Rubella*
Vaccination
Antibodies
Immunoglobulin G
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