- Detection of Anti-Extractable Nuclear Antigens in Patients with Systemic Rheumatic Disease via Fluorescence Enzyme Immunoassay and Its Clinical Utility
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Oh J, Park Y, Lee KA, Kim HS
- KMID: 2466338
- Yonsei Med J.
- 2020 Jan;61(1):73-78.
- doi: 10.3349/ymj.2020.61.1.73
PURPOSE: Testing for autoantibodies to extractable nuclear antigens (ENAs) plays an important role in the diagnosis and management of systemic rheumatic disease. Currently, no gold standard tests are available for... -
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- Inhibitory Effects of Protopanaxadiol on Lipopolysaccharide-Induced Reactive Oxygen Species Production and MUC5AC Expression in Human Airway Epithelial Cells
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Song YS, Kim JH, Na H, Choi YS, Song SY, Kim YD, Bae CH
- KMID: 2461002
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2019 Sep;62(9):507-514.
- doi: 10.3342/kjorl-hns.2018.00920
BACKGROUND AND OBJECTIVES: MUC5AC is one of the major secretory mucin genes in the human airway epithelium. MUC5AC expression is increased by a variety of inflammatory mediators. Protopanaxadiol (PPD), one... -
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- The evaluation of cellular immune function in elderly patients with systemic lupus erythematosus
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Men K, Chen Y, Zhang J, Wei D
- KMID: 2457324
- Korean J Intern Med.
- 2019 Jul;34(4):932-937.
- doi: 10.3904/kjim.2017.224
BACKGROUND/AIMS: To evaluate cellular immune function in systemic lupus erythematosus (SLE) patients over 60 years old, the association between antinuclear antibody (ANA) titers and the ratio of CD4âº/CD8⺠was analyzed... -
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- Endoplasmic Reticulum Stress Induces MUC5AC and MUC5B Expression in Human Nasal Airway Epithelial Cells
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Kim MH, Bae CH, Choi YS, Na HG, Song SY, Kim YD
- KMID: 2447427
- Clin Exp Otorhinolaryngol.
- 2019 May;12(2):181-189.
- doi: 10.21053/ceo.2018.00493
OBJECTIVES: Endoplasmic reticulum (ER) stress is known to be associated with inflammatory airway diseases, and three major transmembrane receptors: double-stranded RNA-activated protein kinase-like ER kinase, inositol requiring enzyme 1, and... -
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- Laboratory Diagnosis of Clostridium difficile Infection in Korea: The First National Survey
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Chung HS, Park JS, Shin BM
- KMID: 2431610
- Ann Lab Med.
- 2019 May;39(3):317-321.
- doi: 10.3343/alm.2019.39.3.317
In May 2015, we conducted a voluntary online survey on laboratory diagnostic assays for Clostridium difficile infection (CDI) across clinical microbiology laboratories in Korea. Responses were obtained from 66 laboratories,... -
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- Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases
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Ünüvar S, Erge D, Kılıçarslan B, Gözükara Bağ HG, Çatal F, Girgin G, Baydar T
- KMID: 2431606
- Ann Lab Med.
- 2019 May;39(3):284-290.
- doi: 10.3343/alm.2019.39.3.284
BACKGROUND: Although Th2 immune activation is predominant in allergic diseases, neopterinlevels and indoleamine 2,3-dioxygenase (IDO)-1 activity (kynurenine:tryptophan ratio), which reflect Th1 immune activity, increase with interferon-gamma (IFN-γ) stimulation. We investigated... -
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- Nkx-2.5 Regulates MDR1 Expression via Its Upstream Promoter in Breast Cancer Cells
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Lim JS, Jung GY, Park SY
- KMID: 2442099
- J Korean Med Sci.
- 2019 Apr;34(12):e100.
- doi: 10.3346/jkms.2019.34.e100
BACKGROUND: Increased expression of MDR1 gene is one of the major mechanisms responsible for multidrug resistance in cancer cells. Two alternative promoters, upstream and downstream, are responsible for transcription of... -
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- Performance Evaluation of Two Immunochromatographic Assays for Rotavirus Detection in Stool Specimens
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Kim S, Kim YJ, Cho SY, Park TS, Lee HJ
- KMID: 2441826
- Lab Med Online.
- 2019 Apr;9(2):73-76.
- doi: 10.3343/lmo.2019.9.2.73
BACKGROUND: Rotavirus is a major pathogen causing enteritis worldwide in children under five years of age. In recent years, immunochromatographic assay (ICA) has been widely used as a diagnostic test... -
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- Performance of Hepatitis B Core-Related Antigen Versus Hepatitis B Surface Antigen and Hepatitis B Virus DNA in Predicting HBeAg-positive and HBeAg-negative Chronic Hepatitis
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Zhang ZQ, Wang YB, Lu W, Liu DP, Shi BS, Zhang XN, Huang D, Li XF, Zhou XL, Ding RR
- KMID: 2420273
- Ann Lab Med.
- 2019 Jan;39(1):67-75.
- doi: 10.3343/alm.2019.39.1.67
BACKGROUND: We examined changes in hepatitis B core-related antigen (HBcrAg) during the four sequential phases of chronic hepatitis B virus (HBV) infection: hepatitis B e antigen (HBeAg)-positive chronic infection (EPCI)... -
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- Triptolide Inhibits Lipopolysaccharide-Induced MUC5AC/5B Expression via Nuclear Factor-Kappa B in Human Airway Epithelial Cells
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Seo BH, Choi TY, Choi YS, Bae CH, Na HG, Song SY, Kim YD
- KMID: 2430846
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2018 Dec;61(12):674-680.
- doi: 10.3342/kjorl-hns.2018.00157
BACKGROUND AND OBJECTIVES: The representative mucin genes in the human airway are MUC5AC and MUC5B, which are regulated by several inflammatory and anti-inflammatory substances. Triptolide (TPL), udenafil, betulinic acid, changkil... -
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- Implementing Expanded Rapid Human Immunodeficiency Virus Testing in Public Health Centers in Seoul, 2015
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Kang CR, Bang JH, Cho SI, Lee YH, Oh MD, Lee JK
- KMID: 2429938
- Infect Chemother.
- 2018 Dec;50(4):346-349.
- doi: 10.3947/ic.2018.50.4.346
In 2015, rapid human immunodeficiency virus (HIV) testing was implemented in all 25 public health centers in Seoul. During March and December 2015, 20,987 rapid HIV tests were performed, of... -
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- Usefulness of fecal calprotectin by monoclonal antibody testing in adult Japanese with inflammatory bowel diseases: a prospective multicenter study
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Nakamura S, Imaeda H, Nishikawa , Iimuro M, Matsuura M, Oka H, Oku J, Miyazaki T, Honda H, Watanabe K, Nakase H, Andoh A
- KMID: 2434157
- Intest Res.
- 2018 Oct;16(4):554-562.
- doi: 10.5217/ir.2018.00027
BACKGROUND/AIMS: Noninvasive objective monitoring is advantageous for optimizing treatment strategies in patients inflammatory bowel disease (IBD). Fecal calprotectin (FCP) is superior to traditional biomarkers in terms of assessing the activity... -
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- Decreased Serum Glutamate Levels in Male Adults with Internet Gaming Disorder: A Pilot Study
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Paik SH, Choi MR, Kwak SM, Bang SH, Kim DJ
- KMID: 2419981
- Clin Psychopharmacol Neurosci.
- 2018 Aug;16(3):276-281.
- doi: 10.9758/cpn.2018.16.3.276
OBJECTIVE: Alteration in glutamatergic neurotransmission and dopaminergic dysfunction has been implicated in both the initiation and expression of addiction related behaviors. This pilot study was aimed to investigate the serum... -
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- Clusterin Induces MUC5AC Expression via Activation of NF-κB in Human Airway Epithelial Cells
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Bae CH, Na HG, Choi YS, Song SY, Kim YD
- KMID: 2412670
- Clin Exp Otorhinolaryngol.
- 2018 Jun;11(2):124-132.
- doi: 10.21053/ceo.2017.00493
OBJECTIVES: Clusterin (CLU) is known as apolipoprotein J, and has three isoforms with different biological functions. CLU is associated with various diseases such as Alzheimer disease, atherosclerosis, and some malignancies.... -
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- Is Clostridium difficile infection a real threat in patients with ulcerative colitis? A prospective, multicenter study in Korea
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Kim DB, Lee KM, Park SH, Kim YS, Kim ES, Lee J, Jung SA, Seo GS, Lee JM
- KMID: 2417678
- Intest Res.
- 2018 Apr;16(2):267-272.
- doi: 10.5217/ir.2018.16.2.267
BACKGROUND/AIMS: Clostridium difficile infection (CDI) has been reported to be a cause of flare-ups in patients with ulcerative colitis (UC). We evaluated the prevalence and clinical outcomes of CDI in... -
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- High Concentration of Glucose Induces MUC5B Expression via Reactive Oxygen Species in Human Airway Epithelial Cells
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Lee YH, Kim YD, Song YS, Bae CH, Choi YS, Shin KC, Jin HJ, Song SY
- KMID: 2390897
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2017 Aug;60(8):396-403.
- doi: 10.3342/kjorl-hns.2017.17601
BACKGROUND AND OBJECTIVES: The effects of hyperglycemia on the mucin secretion in inflammatory respiratory diseases are not clear. Therefore, this study was conducted to characterize the effect of hyperglycemia, and... -
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- Asian Sand Dust Up-Regulates MUC4 Expression in Human Upper Airway Epithelial Cells
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Park CH, Song YS, Bae CH, Choi YS, Song SY, Shin KC, Jin HJ, Kim YD
- KMID: 2379917
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2017 May;60(5):222-231.
- doi: 10.3342/kjorl-hns.2016.17594
BACKGROUND AND OBJECTIVES: Asian sand dust (ASD) is a meteorological phenomenon that occurs in spring time in Korea. ASD is composed of various organic and inorganic materials, which induce airway... -
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- A Simple Outline of Methods for Protein Isolation and Purification
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Lee CH
- KMID: 2413281
- Endocrinol Metab.
- 2017 Mar;32(1):18-22.
- doi: 10.3803/EnM.2017.32.1.18
At the summer workshop of the Korean Endocrine Society held in 2016, some examples of protein experiments were discussed in the session entitled “All about working with proteins.†In contrast... -
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- Effect of High Glucose on MUC5B Expression in Human Airway Epithelial Cells
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Ye SB, Choi YS, Choi YH, Bae CH, Kim YW, Park SY, Song SY, Kim YD
- KMID: 2376412
- Clin Exp Otorhinolaryngol.
- 2017 Mar;10(1):77-84.
- doi: https://doi.org/10.21053/ceo.2016.00045
OBJECTIVES: Excessive production of mucus results in plugging of the airway tract, which can increase morbidity and mortality in affected patients. In patients with diabetes, inflammatory airway disease appears with... -
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- Next-generation sequencing enables the discovery of more diverse positive clones from a phage-displayed antibody library
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Yang W, Yoon A, Lee S, Kim S, Han J, Chung J
- KMID: 2375795
- Exp Mol Med.
- 2017 Mar;49(3):e308.
- doi: 10.1038/emm.2017.22
Phage display technology provides a powerful tool to screen a library for a binding molecule via an enrichment process. It has been adopted as a critical technology in the development... -
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