Korean J Nephrol.
2010 Jan;29(1):104-109.
Three Cases of Minimal Change Nephrotic Syndrome in Patients with Type 2 Diabetes
- Affiliations
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- 1Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine, Korea. jungeun34.lee@samsung.com
- 2Department of Pathology, Samsung Medical Center Sungkyunkwan University School of Medicine, Korea.
Abstract
- Diabetic nephropathy is a common and serious complication of diabetes characterized by persistent proteinuria, hypertension and a progressive decline of renal function. However, non-diabetic renal disease can be present in diabetic patients and differential diagnosis of treatable disease is important. Minimal change nephrotic syndrome is characterized by normal light microscopic finding and effacement of foot process in electron microscope, but foot process effacement is not specific and it can be present in the glomeruli of the most glomerulopathy including diabetic nephropathy. Therefore, pathologic diagnosis of minimal change nephrotic syndrome combined with diabetic nephropathy is very difficult. However, we could exclude other glomerulopathy and diagnose minimal change nephrotic syndrome by clinical features in three type 2 diabetic patients with diabetic nephropathy and have successfully treated with corticosteroid.
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