Korean J Nephrol.  2005 Jan;24(1):71-79.

Renoprotective Effect of the Combined Use of Steroid and Angiotensin II Receptor Blocker in IgA Nephropathy

• Kim YK
• Lee SH
• Lee TW
• Kim MJ
• Yang MH
• Ihm CG

Abstract

BACKGROUND
Several studies have examined the role of angiotensin II receptor blocker (ARB) or steroid treatment in decreasing proteinuria and preserving renal function in IgA nephropathy (IgAN). METHODS: We designed a prospective, randomized trial to assess the effects of combination therapy of steroid (daily high-dose for 6 months) and ARB in IgAN patients with proteinuria >or=1.0 g/d and serum creatinine (SCr)or=1.4 mg/dL at the last visit had older age and higher proteinuria level at 6 mo than those with SCr<1.4 mg/dL. CONCLUSION: It was observed in the patients with IgAN with normal renal function and proteinuria >or=1g/d that the combination of ARB and prednisolone was more effective in preserving renal function as well as in decreasing proteinuria than the ARB alone therapy.

Keyword

Angiotensin II receptor blocker; Prednisolone; IgA nephropathy; Proteinuria; Renal function

MeSH Terms

Angiotensin II*
Angiotensins*
Creatinine
Glomerulonephritis, IGA*
Humans
Immunoglobulin A*
Prednisolone
Prospective Studies
Proteinuria
Receptors, Angiotensin*
Angiotensin II
Angiotensins
Creatinine
Immunoglobulin A
Prednisolone
Receptors, Angiotensin