Korean J Nephrol.  2001 Mar;20(2):277-282.

Effect of Angiotensin II Receptor Blockers in Proteinuric IgA Nephropathy

• Noh JH
• Hwang YC
• Lee TW
• Ihm CG

Abstract

Whether immunosuppressive therapy may have beneficial effects in the treatment of IgA nephropathy remains controversial. ACE inhibitor or angiotensin II receptor antagonist(AIIA) are suggested to reduce urinary protein excretion(Up) in patients with renal diseases. We therefore investigated the effects of the angiotensin II receptor antagonist losartan on the proteinuria and renal function in patients with IgA nephropathy. AIIA reduced blood pressure in patients with hypertension, but there were no significant differences statistically before and after therapy. AIIA reduced Up after 1-4 months(2.8+/-1.1 to 1.1+/-1.0g/24h, p=0.001) and 7-13 months(2.8+/-1.1 to 1.7+/-0.6g/24h, p=0.017). There were no significant changes of serum creatinine levels after AIIA treatment. Cough or angioedema were not observed during AIIA treatment. In conclusion, AIIA may be useful in the treatment of patients with IgA nephropathy and proteinuria.

Keyword

Angiotensin II receptor antagonist; Losartan; Proteinuria; IgA nephropathy

MeSH Terms

Angioedema
Angiotensin II*
Angiotensin Receptor Antagonists*
Angiotensins*
Blood Pressure
Cough
Creatinine
Glomerulonephritis, IGA
Humans
Hypertension
Losartan
Proteinuria
Receptors, Angiotensin*
Angiotensin II
Angiotensin Receptor Antagonists
Angiotensins
Creatinine
Losartan
Receptors, Angiotensin