Study on the Platelet Count and Blood Chemical Tests in Pregnancy Induced Hypertension ( PIH )

Lee, D J; Park, H R; Suk, J H; Choi, E J; Choi, Y S; Choe, Y C; Park, I S

Abstract

This study was undertaken to evaluate the significance of platelet counts and blood chemical assays in predicting pregnancy induced hypertension and differentiating its severity. And so the differences in platelet counts and blood chemical assays between 4 (0~24.9, 25.0~49.9, 50.0~74.9, 75.0~100) birth weight- for-date percentile groups in cases with normal pregnancy, mild and severe pregnancy induced hypertension (PIH) and also between normal pregnancy cases and PIH cases in the same birth weight-for-date percentile group were evaluated. 50 cases with mild PIH, 67 cases with severe PIH, and 82 cases with normal pregnancy for control were taken part in this study at the department of Obstetrics and Gynecology, Fatima Hospital from July, 1996 to June, 1997. Platelet counts, aspartate aminiotransferase (AST), alanine aminotransferase (ALT), total protein, albumin, blood urea nitrogen (BUN) and creatinine levels were measured and analyzed in cases with normal pregnancy, mild and severe PIH according to birth weight-for-date percentile groups. The results were as follows: 1. There was a significant correlation between the birth weight-for-date percentile groups and the pregnancy cases. 62.5% of 0~24.9 birth weight-for-date percentile group were distributed in severe PIH cases and 55.3% of 75.0~100 birth weight-for-date percentile group were distributed in normal pregnancy cases. 2. There was no significant difference on platelet count between each birth weight-for-date percentile groups in cases with normal pregnancy, mild and severe PIH and also between normal pregnancy and mild PIH cases in the same birth weight-for-date percentile group. There were significant differences between normal pregnancy and severe PIH cases in the 25.0~49.9 and 50.0~74.9 birth weight-for-date percentile groups. 3. There was no siginificant difference in serum AST and ALT levels between each birth weight-for-date percentile groups in cases with normal pregnancy, mild and severe PIH and also between normal, mild and severe PIH cases in the same birth weight-for-date percentile group. 4. There was no significant difference in serum total protein levels between each birth weight-for-date percentile groups in cases with normal pregnancy, mild and severe PIH and also between normal pregnancy, mild and severe PIH cases in the same birth weight-for-date percentile group except 0~24.9 birth weight-for-date percentile group. The serum albumin levels in severe PIH cases were significantly different between 0~24.9 and 75.0~100 birth weight-for-date percentile groups. The serum albumin level in severe PIH cases was significantly lower than that in normal pregnancy at 0~24.9 birth weight-for-date percentile group. 5. There was no significant difference in BUN levels between each birth weight-for-date percentile groups in mild and severe PIH cases but a difference was found between normal pregnancy and severe PIH cases in 25.0~49.9 and 50.0~74.9 birth weight-for-date percentile groups. There was no significant difference in serum creatinine levels between each birth weight-for-date percentile groups in normal pregnancy, mild and severe PIH cases and also between normal pregnancy, mild and severe PIH cases in the same birth weight-for-date percentile group.