Korean J Thorac Cardiovasc Surg.  2007 Jun;40(6):435-440.

Clinical Analysis of Primary Malignant Lymphoma of the Lung

• Kim JB
• Park CK
• Park NH
• Kum DY
• Noh DS
• Lee JH
• Han SB
• Jung HR

Abstract

BACKGROUND: Primary malignant lymphoma of the lung is a very rare neoplasm. Although the prognosis of lymphoma is favorable, the clinical features, prognostic factors and management have not been clearly defined. MATERIAL AND METHOD: We retrospectively reviewed the records of 8 patients we managed between 1994 and 2006. They all had malignant lymphoma on the pathologic examination of the lung with no evidence of mediastinal adenopathy and extrathoracic disease, and no past history of lymphoma. RESULT: The study group consisted of 3 males and 5 female patients with a mean age of 53.9 years. Three patients were asymtomatic and 5 patients were seen with pulmonary or systemic symptoms. The diagnostic methods were 3 CT needle aspiration biopsies, 1 bronchoscopic biopsy and 4 surgical methods (wedge resection, lobectomy). There were 3 patients with MALT lymphoma, two with diffuse large B-cell lymphoma, two with small lymphocytic lymphom, and one with follicular lymphoma. The 8 patients were treated with a variety of modalities, including surgery, chemotherapy, radiotherapy and combination therapy. The 8 patients have survived for a median follow-up of 38 months.
CONCLUSION
Although this entity of lymphoma appears to have a good prognosis, further clinical experience and long-term follow-up are needed to identify its clinical features, prognostic factors and management.

Keyword

Lymphoma; Pathology; Lung neoplasm

MeSH Terms

Biopsy
Biopsy, Needle
Drug Therapy
Female
Follow-Up Studies
Humans
Lung Neoplasms
Lung*
Lymphoma*
Lymphoma, B-Cell
Lymphoma, B-Cell, Marginal Zone
Lymphoma, Follicular
Male
Needles
Pathology
Prognosis
Radiotherapy
Retrospective Studies