Korean J Urol.  2001 Oct;42(10):1092-1095.

Effects of Hormones and Age on Prostate Volume and Symptom Score in Patients with Benign Prostatic Hyperplasia

• Kim DS
• Kim YH

Abstract

PURPOSE: Although benign prostatic hyperplasia (BPH) has been shown to increase with age and be influenced by sex hormones, the relationship between aging and hormonal influences on growth of prostate is still unresolved. We studied the relationship of age and androgen on volume of prostate and symptoms of benign prostatic hyperplasia.
MATERIALS AND METHODS
Two hundred and ten men with BPH were evaluated using transrectal ultrasonography, and international prostate symptom score for BPH. In all patients, the following parameters were obtained by serum analysis: prostate-specific antigen (PSA), luteinizing hormone (LH), follicle stimulating hormone (FSH), total testosterone, free testosterone, dihydrotestosterone (DHT) and prolactin.
RESULTS
With age, there was a significant increase in the prostate volume, serum LH, FSH, and PSA, and a significant decrease in serum free testosterone. However, prostate volume and IPSS were not correlated with measured serum hormones.
CONCLUSIONS
Our data do not suggest that testosterone act on the development of BPH and lower urinary tract symptoms. However, because the levels of circulating hormones do not necessarily reflect their intraprostatic concentrations, molecular biologic studies and prospective clinical studies may be needed to establish the linkage between hormones levels and BPH.

Keyword

BPH; Prostate volume; Testosterone; Age; IPSS

MeSH Terms

Aging
Dihydrotestosterone
Follicle Stimulating Hormone
Gonadal Steroid Hormones
Humans
Lower Urinary Tract Symptoms
Luteinizing Hormone
Male
Prolactin
Prostate*
Prostate-Specific Antigen
Prostatic Hyperplasia*
Testosterone
Ultrasonography
Dihydrotestosterone
Follicle Stimulating Hormone
Gonadal Steroid Hormones
Luteinizing Hormone
Prolactin
Prostate-Specific Antigen
Testosterone