J Korean Cancer Assoc.  1997 Oct;29(5):867-873.

Immunohistochemical Study on Expression of the p53 Protein in Medulloblastoma/PNET

Affiliations
  • 1Department of Pediatrics, Dong-A University College of Medicine, Korea.
  • 2Department of Pathology, Dong-A University College of Medicine, Korea.
  • 3Department of Pediatrics, Inje University Pusan Paik Hospital, Pusan, Korea.
  • 4Department of Pathology, Inje University Pusan Paik Hospital, Pusan, Korea.
  • 5Department of Pediatrics, Pusan National University College of Medicine, Pusan, Korea.
  • 6Department of Pathology, Pusan National University College of Medicine, Pusan, Korea.

Abstract

PURPOSE: The present study explores the expression rate of p53 mutation and the correlation between the expression of p53 protein and prognostic factors in medulloblastoma/ PNET (primitive neuroectodermal tumor).
MATERIALS AND METHODS
We studied retrospectively 24 patients with medulloblastoma/ PNET, who were admitted in Dong-A University Hospital, Pusan National University Hospital and Inje University Pusan Paik Hospital from 1988 to 1995. Detection of p53 mutations was made by immunohistochemical staining of p53 protein on paraffin- embedded tissues. The correlation between the expression of p53 protein and prognostic factors was evaluated by the Spearman correlation analysis.
RESULTS
p53 protein was expressed in 6 of 24 patients (25%). In 20 patients who could be evaluated for metastasis, 16 patients of M0, 1 patient of M1 and 3 patients of M2 were grouped by M stage, and the expression of p53 was detected in 1 of 16 M0 group (6.3%) and 3 of 3 M2 group (100%). p53 expression was significantly related to the M stage of medulloblastoma/PNET (r=0.73, p<0.001). The detection of p53 was not significantly associated with T stage, cellular differentiation and the relapse rate of medulloblastoma/ PNET.
CONCLUSION
The immunohistochemical detection rate of p53 protein in medulloblastoma/ PNET was 25%. The expression of p53 protein was significantly related to the M stage, with higher expression rate in M2 group of medulloblsatoma/PNET.

Keyword

Medulloblastoma; Primitive neuroectodermal tumor; Immunohistochemical stain; p53
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