J Korean Cancer Assoc.  1997 Oct;29(5):867-873.

Immunohistochemical Study on Expression of the p53 Protein in Medulloblastoma/PNET

Affiliations
  • 1Department of Pediatrics, Dong-A University College of Medicine, Korea.
  • 2Department of Pathology, Dong-A University College of Medicine, Korea.
  • 3Department of Pediatrics, Inje University Pusan Paik Hospital, Pusan, Korea.
  • 4Department of Pathology, Inje University Pusan Paik Hospital, Pusan, Korea.
  • 5Department of Pediatrics, Pusan National University College of Medicine, Pusan, Korea.
  • 6Department of Pathology, Pusan National University College of Medicine, Pusan, Korea.

Abstract

PURPOSE
The present study explores the expression rate of p53 mutation and the correlation between the expression of p53 protein and prognostic factors in medulloblastoma/ PNET (primitive neuroectodermal tumor).
MATERIALS AND METHODS
We studied retrospectively 24 patients with medulloblastoma/ PNET, who were admitted in Dong-A University Hospital, Pusan National University Hospital and Inje University Pusan Paik Hospital from 1988 to 1995. Detection of p53 mutations was made by immunohistochemical staining of p53 protein on paraffin- embedded tissues. The correlation between the expression of p53 protein and prognostic factors was evaluated by the Spearman correlation analysis.
RESULTS
p53 protein was expressed in 6 of 24 patients (25%). In 20 patients who could be evaluated for metastasis, 16 patients of M0, 1 patient of M1 and 3 patients of M2 were grouped by M stage, and the expression of p53 was detected in 1 of 16 M0 group (6.3%) and 3 of 3 M2 group (100%). p53 expression was significantly related to the M stage of medulloblastoma/PNET (r=0.73, p<0.001). The detection of p53 was not significantly associated with T stage, cellular differentiation and the relapse rate of medulloblastoma/ PNET.
CONCLUSION
The immunohistochemical detection rate of p53 protein in medulloblastoma/ PNET was 25%. The expression of p53 protein was significantly related to the M stage, with higher expression rate in M2 group of medulloblsatoma/PNET.

Keyword

Medulloblastoma; Primitive neuroectodermal tumor; Immunohistochemical stain; p53
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