- 8-Methoxypsoralen Induces Apoptosis by Upregulating p53 and Inhibits Metastasis by Downregulating MMP-2 and MMP-9 in Human Gastric Cancer Cells
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Choi EK, Kim HD, Park EJ, Song SY, Phan TT, Nam M, Kim M, Kim DU, Hoe KL
- KMID: 2539591
- Biomol Ther.
- 2023 Mar;31(2):219-226.
- doi: 10.4062/biomolther.2023.004
Furanocoumarin 8-methoxypsoralen (8-MOP) is the parent compound that naturally occurs in traditional medicinal plants used historically. 8-MOP has been employed as a photochemotherapeutic component of Psoralen + Ultraviolet A (PUVA)... -
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- MHY2251, a New SIRT1 Inhibitor, Induces Apoptosis via JNK/p53 Pathway in HCT116 Human Colorectal Cancer Cells
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Kang YJ, Kwon YH, Jang JY, Lee JH, Lee S, Park Y, Moon HR, Chung HY, Kim ND
- KMID: 2537583
- Biomol Ther.
- 2023 Jan;31(1):73-81.
- doi: 10.4062/biomolther.2022.044
Sirtuins (SIRTs) belong to the nicotinamide adenine dinucleotide (NAD+)-dependent class III histone deacetylase family. They are key regulators of cellular and physiological processes, such as cell survival, senescence, differentiation, DNA... -
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- Somatic Mutations of TP53 Identified by Targeted Next-Generation Sequencing Are Poor Prognostic Factors for Primary Operable Breast Cancer: A Single-Center Study
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Park JH, Kwon MJ, Seo J, Kim HY, Min SK, Kim LS
- KMID: 2534775
- J Breast Cancer.
- 2022 Oct;25(5):379-386.
- doi: 10.4048/jbc.2022.25.e41
Few studies have reported on the clinical utility of targeted next-generation sequencing (NGS) for breast cancer in Korea. We retrospectively reviewed the targeted NGS data of 219 patients with breast... -
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- Clinical outcomes of immunohistochemistry of the p53 Staining pattern in high-grade serous ovarian carcinoma
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Orachum P, Temtanakitpaisan A, Kleebkaow P, Chumworathayi B, Luanratanakorn S, Aue-angkul A, Itarat Y
- KMID: 2533819
- Obstet Gynecol Sci.
- 2022 Sep;65(5):459-467.
- doi: 10.5468/ogs.22102
Objective To investigate the prevalence of p53 mutations and associated factors between immunohistochemistry (IHC) and p53 staining patterns among patients with high-grade serous ovarian carcinoma (HGSOC). Methods This study is a retrospective review.... -
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- The Risk of Gastrointestinal Cancer on Daily Intake of Low-Dose BaP in C57BL/6 for 60 Days
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Zheng Z, Park JK, Kwon OW, Ahn SH, Kwon YJ, Jiang L, Zhu S, Park BH
- KMID: 2532229
- J Korean Med Sci.
- 2022 Aug;37(30):e235.
- doi: 10.3346/jkms.2022.37.e235
Background: Benzo(a)pyrene (BaP) is a carcinogenic compound in contaminated foodstuffs. The effect of oral intake of the environmental carcinogen BaP under low doses and frequent exposure on a digestive system has... -
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- Snail Promotes Cancer Cell Proliferation via Its Interaction with the BIRC3
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Rho SB, Byun HJ, Kim BR, Lee CH
- KMID: 2531003
- Biomol Ther.
- 2022 Jul;30(4):380-388.
- doi: 10.4062/biomolther.2022.063
Snail is implicated in tumour growth and metastasis and is up-regulated in various human tumours. Although the role of Snails in epithelial-mesenchymal transition, which is particularly important in cancer metastasis,... -
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- TP53 variants in p53 signatures and the clonality of STICs in RRSO samples
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Akahane T, Masuda K, Hirasawa A, Kobayashi Y, Ueki A, Kawaida M, Misu K, Nakamura K, Nagai S, Chiyoda T, Yamagami W, Hayashi S, Kataoka F, Banno K, Sugano K, Okita H, Kosaki K, Nishihara H, Aoki D
- KMID: 2537895
- J Gynecol Oncol.
- 2022 Jul;33(4):e50.
- doi: 10.3802/jgo.2022.33.e50
Objective Precursor lesions may be identified in fallopian tube tissue after risk-reducing salpingo-oophorectomy (RRSO) in patients with pathogenic variants of BRCA1/2. Serous tubal intraepithelial carcinoma (STIC) is considered a precursor of... -
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- Clinicopathological and molecular characterization of high-grade endometrial carcinoma with POLE mutation: a single center study
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Yu S, Sun Z, Zong L, Yan J, Yu M, Chen J, Lu Z
- KMID: 2536988
- J Gynecol Oncol.
- 2022 May;33(3):e38.
- doi: 10.3802/jgo.2022.33.e38
Objective The molecular classification system of endometrial carcinoma (EC) in ‘The Cancer Genome Atlas’ is widely acknowledged for its prognostic utility. Subsequently, more simplified classification system that incorporate DNA polymerase epsilon... -
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- Molecular docking of bioactive compounds derived from Moringa oleifera with p53 protein in the apoptosis pathway of oral squamous cell carcinoma
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Rath S, Jagadeb M, Bhuyan R
- KMID: 2524337
- Genomics Inform.
- 2021 Dec;19(4):e46.
- doi: 10.5808/gi.21062
Moringa oleifera is nowadays raising as the most preferred medicinal plant, as every part of the moringa plant has potential bioactive compounds which can be used as herbal medicines. Some... -
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- p53 Promotes Differentiation of Cardiomyocytes from hiPSC through Wnt Signaling-Mediated Mesendodermal Differentiation
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Liu Y, Zhang P, Huang W, Liu F, Long D, Peng W, Dang X, Zeng X, Zhou R
- KMID: 2522560
- Int J Stem Cells.
- 2021 Nov;14(4):410-422.
- doi: 10.15283/ijsc21051
Background and Objectives: Manipulating different signaling pathways via small molecules could efficiently induce cardiomyocytes from human induced pluripotent stem cells (hiPSC). However, the effect of transcription factors on the hiPSC-directed cardiomyocytes... -
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- Histopathological Analysis of Esophageal Mucosa in Patients with Achalasia
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Lee BE, Kim GH, Shin N, Park DY, Song GA
- KMID: 2520123
- Gut Liver.
- 2021 Sep;15(5):713-722.
- doi: 10.5009/gnl20195
Background/Aims: Achalasia is an esophageal motor disorder that leads to functional esophageal obstruction. Food stasis and bacterial fermentation can predispose an individual to esophageal mucosal inflammation, causing multifocal dysplasia and... -
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- Mutations of p53 associated with pancreatic cancer and therapeutic implications
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Voutsadakis IA
- KMID: 2519287
- Ann Hepatobiliary Pancreat Surg.
- 2021 Aug;25(3):315-327.
- doi: 10.14701/ahbps.2021.25.3.315
Pancreatic adenocarcinoma is a malignancy with rising incidence and grim prognosis. Despite improvements in therapeutics for treating metastatic pancreatic cancer, this disease is invariably fatal with survival time less than... -
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- Luteolin inhibits H2O2 -induced cellular senescence via modulation of SIRT1 and p53
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Zhu RZ, Li BS, Gao SS, Seo JH, Choi BM
- KMID: 2516869
- Korean J Physiol Pharmacol.
- 2021 Jul;25(4):297-305.
- doi: 10.4196/kjpp.2021.25.4.297
Luteolin, a sort of flavonoid, has been reported to be involved in neuroprotective function via suppression of neuroinflammation. In this study, we investigated the protective effect of luteolin against oxidative... -
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- Clinical Features of Breast Cancer in South Korean Patients with Germline TP53 Gene Mutations
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Alyami H, Yoo TK, Cheun JH, Lee HB, Jung SM, Ryu JM, Bae SJ, Jeong J, Yoon CI, Ahn J, Paik PS, Cho MK, Park WC
- KMID: 2515175
- J Breast Cancer.
- 2021 Apr;24(2):175-182.
- doi: 10.4048/jbc.2021.24.e16
Purpose: Li-Fraumeni syndrome (LFS) is a rare autosomal cancer syndrome caused by a germline mutation in the TP53 gene. Breast cancer in LFS patients is of various subtypes; however, limited data... -
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- MicroRNA-552 expression in colorectal cancer and its clinicopathological significance
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Im J, Nam SK, Lee HS
- KMID: 2513898
- J Pathol Transl Med.
- 2021 Mar;55(2):125-131.
- doi: 10.4132/jptm.2021.01.17
Background: MicroRNA-552 (miR-552) has been reported to correlate with the development and progression of various cancers, including colorectal cancer (CRC). This study aimed to investigate miR-552 expression in cancer tissue... -
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- Prediction of TP53 mutations by p53 immunohistochemistry and their prognostic significance in gastric cancer
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Hwang HJ, Nam SK, Park H, Park Y, Koh J, Na HY, Kwak Y, Kim WH, Lee HS
- KMID: 2506271
- J Pathol Transl Med.
- 2020 Sep;54(5):378-386.
- doi: 10.4132/jptm.2020.06.01
Background: Recently, molecular classifications of gastric cancer (GC) have been proposed that include TP53 mutations and their functional activity. We aimed to demonstrate the correlation between p53 immunohistochemistry (IHC) and... -
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- Econazole Induces p53-Dependent Apoptosis and Decreases Metastasis Ability in Gastric Cancer Cells
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Choi EK, Park EJ, Phan TT, Kim HD, Hoe KL, Kim DU
- KMID: 2503477
- Biomol Ther.
- 2020 Jul;28(4):370-379.
- doi: 10.4062/biomolther.2019.201
Econazole, a potent broad-spectrum antifungal agent and a Ca2+ channel antagonist, induces cytotoxicity in leukemia cells and is used for the treatment of skin infections. However, little is known about... -
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- Prognostic impact of p16 and p53 gene expressions in stage 1a epithelial ovarian cancer
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Günakan E, Tohma YA, Karakaş LA, Akıllı H, Haberal AN, Ayhan A
- KMID: 2505036
- Obstet Gynecol Sci.
- 2020 Jul;63(4):464-469.
- doi: 10.5468/ogs.19204
Objective Epithelial ovarian cancer (EOC) is rarely detected at stage 1a. Most of the patients have a good prognosis and there are limited factors that affect their survival. In the present... -
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- Prognostic Value of TP53 Mutation for Transcatheter Arterial Chemoembolization Failure/Refractoriness in HBV-Related Advanced Hepatocellular Carcinoma
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Xue M, Wu Y, Fan W, Guo J, Wei J, Wang H, Tan J, Wang Y, Yao W, Zhao Y, Li J
- KMID: 2504471
- Cancer Res Treat.
- 2020 Jul;52(3):925-937.
- doi: 10.4143/crt.2019.533
Purpose This study aimed to investigate the clinicopathologic features and mutational landscape of patients with hepatitis B virus (HBV)–related advanced hepatocellular carcinomas (HCC) undergoing transcatheter arterial chemoembolization (TACE). Materials and Methods From January... -
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- Differences in prognosis by p53 expression after neoadjuvant chemotherapy in triple-negative breast cancer
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Bae SY, Lee JH, Bae JW, Jung SP
- KMID: 2502114
- Ann Surg Treat Res.
- 2020 Jun;98(6):291-298.
- doi: 10.4174/astr.2020.98.6.291
Purpose: Our previous studies suggested that p53-positive triple-negative breast cancer (TNBC) should be more sensitive to chemotherapy than p53-negative TNBC. The aim of this study was to determine whether p53... -
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