J Korean Med Sci.  1993 Oct;8(5):325-328. 10.3346/jkms.1993.8.5.325.

Patterns of p53 expression in phyllodes tumors of the breast: an immunohistochemical study

• Kim CJ
• Kim WH

• KMID: 1421998
• DOI: http://doi.org/10.3346/jkms.1993.8.5.325

Abstract

Authors performed an immunohistochemical analysis using monoclonal antibody to p53 protein on 15 cases of benign and malignant phyllodes tumor of the breast along with a review of other conventional clinicopathological parameters to investigate the meaning of p53 expression. The cases were composed of 8 benign and 7 malignant lesions. The pattern of p53 expression showed a statistically significant difference between these benign and malignant lesions (p<0.005). None of the benign cases expressed p53 whereas 6 out of 7 malignant cases did. Among malignant phyllodes tumors, the pattern of expression was diffuse and strong in two cases while granular and relatively weak in the remaining 4 cases. p53 expression seemed to be a unique feature of malignant phyllodes tumors, thereby, one of the most significant parameters for the differentiation of benign and malignant phyllodes tumors of the breast.

Keyword

p53; Phyllodes tumor; Cystosarcoma phyllodes; Breast neoplasm

MeSH Terms

Adult
Breast Neoplasms/*chemistry/pathology
Female
Genes, p53
Humans
Immunohistochemistry
Middle Aged
Phyllodes Tumor/*chemistry/pathology
Tumor Suppressor Protein p53/*analysis
Tumor Suppressor Protein p53