J Clin Pathol Qual Control.  1998 Dec;20(2):417-422.

Evaluation of ACS : 180SE Automated Chemiluminescence Immunoassay System

  • 1Department of Clinical Pathology, Yonsei University Wonju College of Medicine, Korea.
  • 2Department of Clinical Pathology, Wonjum and College of Medicine, Hallym University, Choonchun, Korea.


BACKGROUND: Radioimmunoassay (RIA) has contributed to diagnostic medicine but the use of radioactive tracer complicates their routine use. Perhaps the most promising candidate is chemiluminescence immunoassay (CLIA), which is based on the detection of light emitted as the result of a chemical reaction, potentially can exhibit even greater sensitivity than RIA.
We evaluated the technical performance of the Ciba Corning ACS:180SE automated chemiluminescence immunoassay system for following analytes: trithyroxine, thyroxine, free thyroxine, thyroid simulating hormone, follicle-stimulating hormone, luteinizing hormone, prolactin, alpha-feto protein, carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 125, prostate specific antigen, and ferritin. The characteristics evaluated were linearity, precision, and comparison with the results of radioimmunoassay (RIA).
The within-run precision were from 0.94 to 21.70% and between-run precision 2.75 to 15.19%. The range of linearity was statistically acceptable for all analytes. The correlation coefficient between the value determined by ACS:180SE and RIA was above 0.90.
We conclude that ACS:180SE system is a rapid and precise, and offers safety and time advantages over conventional RIA techniques.

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