Nucl Med Mol Imaging.  2010 Apr;44(1):69-74.

Factors Affecting Changes in the Glomerular Filtration Rate after Unilateral Nephrectomy in Living Kidney Donors and Patients with Renal Disease

• Kim HO
• Chae SY
• Baek S
• Moon DH

Abstract

PURPOSE
We evaluated the factors affecting changes in the postoperative glomerular filtration rate (GFR) after unilateral nephrectomy in living kidney donors and patients with renal disease.
METHODS
We studied 141 subjects who underwent living donor nephrectomy for renal transplantation (n=75) or unilateral nephrectomy for renal diseases (n=66). The GFR of the individual kidney was determined by Tc-99m DTPA scintigraphy before and after nephrectomy. By performing multiple linear regression analysis, we evaluated the factors that are thought to affect changes in GFR, such as age, sex, body mass index (BMI), preoperative GFR, preoperative creatinine level, operated side, presence of diabetes mellitus (DM), presence of hypertension (HTN), and duration of follow-up.
RESULTS
In both the donor nephrectomy and the disease nephrectomy groups, GFR increased significantly after nephrectomy (46.9+/-8.4 to 58.1+/-12.5 vs. 43.0+/-9.6 to 48.6+/-12.8 ml/min, p<0.05). In the donor nephrectomy group, age was significantly associated with change in GFR (beta=-0.3, p<0.005). In the disease nephrectomy group, HTN, preoperative creatinine level, and age were significantly associated with change in GFR (beta=-6.2, p<0.005; beta=-10.9, p<0.01; beta=-0.2, p<0.01, respectively). This compensatory change in GFR was not significantly related to sex, duration of follow-up, or operated side in either group.
CONCLUSIONS
The compensatory change in the GFR of the remaining kidney declined with increasing age in both living kidney donors and patients with renal disease.

Keyword

Tc-99m DTPA scan; Glomerular filtration rate; Unilateral nephrectomy; Age

MeSH Terms

Body Mass Index
Creatinine
Diabetes Mellitus
Follow-Up Studies
Glomerular Filtration Rate
Humans
Hypertension
Kidney
Kidney Transplantation
Linear Models
Living Donors
Nephrectomy
Pentetic Acid
Tissue Donors
Creatinine
Pentetic Acid