Clin Pediatr Hematol Oncol.  2010 Apr;17(1):69-75.

A Case of Infantile Hepatic Hemangioendothelioma Successfully Treated with Interferon-alpha

Affiliations
  • 1Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. hl.jung@samsung.com

Abstract

Infantile hemangioendothelioma is a rare benign, but intermediate to aggressive vascular tumor with potentially life-threatening complications such as high output congestive heart failure or Kasabach-Merritt syndrome. IHE is the most common hepatic vascular tumor and the third most common hepatic tumor in children, usually developing in infants less than 6 months of age. Serum alpha-fetoprotein level has been used as an important tumor marker for malignant hepatic tumors such as hepatoblastoma, hepatocellular carcinoma, and germ cell tumors. Steroids and interferon-alpha are two commonly used agents for medical treatment in IHE. We report a 5-month-old female infant with multiple hepatic hemangioendotheliomas associated with elevation of serum alpha-fetoprotein level, who was successfully treated with interferon-alpha.

Keyword

Infantile hepatic hemangioendothelioma; alpha-interferon; alpha-fetoprotein

MeSH Terms

alpha-Fetoproteins
Carcinoma, Hepatocellular
Child
Female
Heart Failure
Hemangioendothelioma
Hepatoblastoma
Humans
Infant
Interferon-alpha
Kasabach-Merritt Syndrome
Neoplasms, Germ Cell and Embryonal
Steroids
Interferon-alpha
Steroids
alpha-Fetoproteins
Full Text Links
  • CPHO
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2023 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr