Biomol Ther.  2013 Sep;21(5):343-348.

Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin

  • 1Enprani Co., Ltd. R&D Center of Skin Science and Cosmetics, Incheon 400-103, Republic of Korea.
  • 2Bioinformatics & Molecular Design Research Center, Seoul 120-749, Republic of Korea.
  • 3Department of Genetic Engineering, Graduate School of Biotechnology and Skin Biotechnology Center, Kyung Hee University, 446-701 Yongin, Republic of Korea.


We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with alpha-melanocyte stimulating hormone (alpha-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent.


Hesperidin; Melanosome transport; Rab27A; Melanophilin; Pigmented reconstructed epidermis model
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