- Evaluation of General Toxicity and Genotoxicity of the Silkworm Extract Powder
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Heo HS, Choi JH, Oh JJ, Lee WJ, Kim SS, Lee DH, Lee HK, Song SW, Kim KH, Choi YK, Ryu KS, Kang BH
- KMID: 2317845
- Toxicol Res.
- 2013 Dec;29(4):263-278.
The silkworm extract powder contain 1-deoxynojirimycin (DNJ), a potent alpha-glycosidase inhibitor, has therapeutic potency against diabetes mellitus. Therefore, natural products containing DNJ from mulberry leaves and silkworm are consumed as... -
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- Natural Course of Crohn's Disease and Novel Treatment Drugs
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Lee JH, Cheon JH
- KMID: 2267741
- Korean J Med.
- 2013 Dec;85(6):578-585.
Crohn's disease is a chronic recurrent inflammatory disease, mainly affecting the gastrointestinal tract. The pathogenesis of inflammatory bowel disease is believed to be caused by the complex interplay of many... -
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- Biological Therapy for the Prevention and Treatment of Postoperative Endoscopic Recurrence in Crohn's Disease: Time for Acceptance?
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Kotze PG, Saad-Hossne R
- KMID: 2284912
- Intest Res.
- 2013 Oct;11(4):256-260.
- doi: 10.5217/ir.2013.11.4.256
In most patients, postoperative endoscopic recurrence (PER) occurs 1 year after abdominal resection for Crohn's disease (CD). Preventing PER is essential for disease control, as most patients develop further clinical... -
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- Recent Updates on Acetaminophen Hepatotoxicity: The Role of Nrf2 in Hepatoprotection
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Gum SI, Cho MK
- KMID: 2317831
- Toxicol Res.
- 2013 Sep;29(3):165-172.
Acetaminophen (APAP) known as paracetamol is the main ingredient in Tylenol, which has analgesic and anti-pyretic properties. Inappropriate use of APAP causes major morbidity and mortality secondary to hepatic failure.... -
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- Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin
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Kim B, Lee JY, Lee HY, Nam KY, Park J, Lee SM, Kim JE, Lee JD, Hwang JS
- KMID: 2048304
- Biomol Ther.
- 2013 Sep;21(5):343-348.
We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug... -
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- The Effects of Phlomis umbrosa Turcz on Osteoclast Differentiation
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Baek JM, Park JH, Song JH, Park SN, Jeong WJ, Moon SY, Lee CH, Choi MK, Kim JJ, Oh J, Jang SJ
- KMID: 1488822
- Korean J Phys Anthropol.
- 2013 Sep;26(3):115-123.
- doi: 10.11637/kjpa.2013.26.3.115
Many bone-related diseases such as osteoporosis, rheumatoid arthritis are occurred by excessive bone resorbing activity of osteoclasts. Recently, many studies have been proceeded to find out the new therapeutic materials... -
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- A Novel Compound Rasatiol Isolated from Raphanus sativus Has a Potential to Enhance Extracellular Matrix Synthesis in Dermal Fibroblasts
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Roh SS, Park SB, Park SM, Choi BW, Lee MH, Hwang YL, Kim CH, Jeong HA, Kim CD, Lee JH
- KMID: 2265871
- Ann Dermatol.
- 2013 Aug;25(3):315-320.
- doi: 10.5021/ad.2013.25.3.315
BACKGROUND: The fibrous proteins of extracellular matrix (ECM) produced by dermal fibroblast contributes to the maintenance of connective tissue integrity. OBJECTIVE: This study is carried out to identify the bioactive ingredient... -
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- Refractory Plaque Psoriasis Treated with a Combination of Etanercept and Low Dose Methotrexate
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Lim HS, Yun SJ, Lee JB, Kim SJ, Won YH, Lee SC
- KMID: 2388395
- Korean J Dermatol.
- 2013 Jun;51(6):438-441.
Etanercept has been proven to be highly effective to moderate severe plaque psoriasis. Alternative biologics or combination therapies of etanercept with other systemic agents have been recommended to patients who... -
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- Investigation into the Use of Complementary and Alternative Medicine and Factors Affecting Use in Korean Patients with Brain Tumors
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Shin YS, Lee JA, Bae SH, Lee SY, Jang MK
- KMID: 2295631
- J Korean Acad Fundam Nurs.
- 2013 May;20(2):147-156.
PURPOSE: The study was done to define complementary and alternative medicine (CAM) use among primary brain tumor patients and factors influencing use. METHODS: The study was conducted with convenience sampling in... -
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- Chemoprevention of Gastrointestinal Cancer: The Reality and the Dream
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Chun KS, Kim EH, Lee S, Hahm KB
- KMID: 2135063
- Gut Liver.
- 2013 Mar;7(2):137-149.
Despite substantial progress in screening, early diagnosis, and the development of noninvasive technology, gastrointestinal (GI) cancer remains a major cause of cancer-associated mortality. Chemoprevention is thought to be a realistic... -
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- Pityriasis Rubra Pilaris Treated with Infliximab
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Choi JS, Kim JH, Yun JH, Kang HK, Baek JO, Lee JR, Roh JY
- KMID: 2302402
- Korean J Dermatol.
- 2012 Nov;50(11):982-986.
Pityriasis rubra pilaris (PRP) is a chronic papulosquamous disorder of unknown etiology, which may pose therapeutic challenges. There is currently no universally effective treatment for PRP, and some cases are... -
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- Radical Surgical Excision and Use of Lateral Thoracic Flap for Intractable Axillary Hidradenitis Suppurativa
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Teo WL, Ong YS, Tan BK
- KMID: 2120720
- Arch Plast Surg.
- 2012 Nov;39(6):663-666.
- doi: 10.5999/aps.2012.39.6.663
Current treatments for hidradenitis suppurativa (HS) include prolonged courses of antibiotics, retinoids, immunosuppressants, and biologics. Severe cases that are resistant to prolonged medical treatment pose a therapeutic challenge. We propose... -
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- Immunologic Evaluation of Drug Allergy
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Gomez E, Torres MJ, Mayorga C, Blanca M
- KMID: 2167043
- Allergy Asthma Immunol Res.
- 2012 Sep;4(5):251-263.
- doi: 10.4168/aair.2012.4.5.251
Hypersensitivity drug reactions (HDR) consist of an individual abnormal response with the involvement of the immunological system. In addition to specific immunological mechanisms where specific antibodies or sensitised T cells... -
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- Long Term Treatment Concepts and Proactive Therapy for Atopic Eczema
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Wollenberg A, Ehmann LM
- KMID: 2265296
- Ann Dermatol.
- 2012 Aug;24(3):253-260.
- doi: 10.5021/ad.2012.24.3.253
Atopic eczema, also known as atopic dermatitis, is a frequent, highly pruritic, chronic skin disease, which is typically running in flares. The traditional treatment mainly consists of the reactive application... -
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- A Case of Development of Vitiligo Followed by TNF-alpha Antagonist Treatment for Rheumatoid Arthritis
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Song R, Kim SM, Lee SH, Lee YA, Hong SJ, Cho HR, Kim GY, Yang HI
- KMID: 2223074
- J Rheum Dis.
- 2012 Aug;19(4):216-219.
- doi: 10.4078/jrd.2012.19.4.216
As the usage of biologics for rheumatic diseases increases, such as rheumatoid arthritis and ankylosing spondylitis, various cutaneous adverse events are also being increasingly reported. We experienced a case of... -
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- Developmental Strategy for Stem Cell Therapy Products in Regulatory Considerations
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Chang IY, Kim KS
- KMID: 1436775
- Hanyang Med Rev.
- 2012 Aug;32(3):163-169.
- doi: 10.7599/hmr.2012.32.3.163
Expectation that stem cell therapy products will prove better and more effective in treating a variety of medical conditions continues to drive expanding research efforts. Stem cell therapy products consist... -
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- Small Molecule Inhibitors in Rheumatoid Arthritis
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Lee EB
- KMID: 2223092
- J Rheum Dis.
- 2012 Jun;19(3):118-124.
- doi: 10.4078/jrd.2012.19.3.118
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease predominantly affecting diarthroidal joints. Following the successful application of biologic agents, several small molecule inhibitors are currently under clinical trials. Small... -
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- Targeted Therapy in Inflammatory Bowel Disease; Current Status and Future Perspectives
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Jang BI
- KMID: 2168202
- Hanyang Med Rev.
- 2012 May;32(2):94-102.
- doi: 10.7599/hmr.2012.32.2.94
Novel biologic agents that selectively target specific molecules and pathways have been developed recently for the management of inflammatory bowel disease (IBD). Anti-TNF-alpha, an antibody to TNF-alpha is one of... -
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- Novel Pharmacologic Therapies in the Treatment of Systemic Lupus Erythematosus
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Shim SC
- KMID: 2168201
- Hanyang Med Rev.
- 2012 May;32(2):83-93.
- doi: 10.7599/hmr.2012.32.2.83
Systemic lupus erythematosus (lupus) is an autoimmune disease that affects primarily women, especially those of reproductive age. Lupus is a prototypic organ non-specific autoimmune disease that may affect any organ... -
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- Tailored Treatment of Ankylosing Spondylitis
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Kim TJ
- KMID: 2168200
- Hanyang Med Rev.
- 2012 May;32(2):77-82.
- doi: 10.7599/hmr.2012.32.2.77
Ankylosing spondylitis (AS) is a chronic rheumatic disease of the axial skeleton (spine and sacroiliac joints). Only nonsteroidal anti-inflammatory drugs (NSAIDs) and tumor necrosis factor (TNF) alpha inhibitors have currently... -
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